Calcium and cancer:: targeting Ca2+ transport

被引：554

作者：

Monteith, Gregory R. ^{[1
]}

McAndrew, Damara ^{[1
]}

Faddy, Helen M. ^{[1
]}

Roberts-Thomson, Sarah J. ^{[1
]}

机构：

[1] Univ Queensland, Sch Pharm, Brisbane, Qld 4072, Australia

来源：

NATURE REVIEWS CANCER | 2007年 / 7卷 / 07期

关键词：

D O I：

10.1038/nrc2171

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Ca2+ is a ubiquitous cellular signal. Altered expression of specific Ca2+ channels and pumps are characterizing features of some cancers. The ability of Ca2+ to regulate both cell death and proliferation, combined with the potential for pharmacological modulation, offers the opportunity for a set of new drug targets in cancer. However, the ubiquity of the Ca2+ signal is often mistakenly presumed to thwart the specific therapeutic targeting of proteins that transport Ca2+. This Review presents evidence to the contrary and addresses the question: which Ca2+ channels and pumps should be targeted?

引用

页码：519 / 530

页数：12

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