One-Pot Double Benzylation of 2-Substituted Pyridines using Palladium-Catalyzed Decarboxylative Coupling of sp2 and sp3 Carbons

被引：8
|
作者：
Wang, Yaping [1 ]
Li, Xinjian [1 ]
Leng, Faqiang [1 ]
Zhu, Helong [1 ]
Li, Jingya [2 ]
Zou, Dapeng [1 ,2 ]
Wu, Yangjie [1 ]
Wu, Yusheng [2 ,3 ]
机构：
[1] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Peoples R China
[2] Tetranov Biopharm LLC, Zhengzhou, Peoples R China
[3] Tetranov Int Inc, New Brunswick, NJ 08901 USA
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2014年 / 356卷 / 16期
关键词：
benzyl bromide; sp2-sp3; cross-coupling; decarboxylation; double benzylation; 2-picolinic acids; AROMATIC CARBOXYLATE SALTS; ALPHA-OXOCARBOXYLIC ACIDS; ARYL HALIDES; MECHANISM; TRANSFORMATIONS; ALKENYLATION; BROMIDES; KETONES; BONDS;
D O I：
10.1002/adsc.201400311
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
An efficient and practical decarboxylative double benzylation method for various 2-picolinic acids has been established by using a bimetallic catalytic system of palladium(II) chloride (PdCl2) and silver(I) oxide (Ag2O), which offered a variety of diarylmethane derivatives with moderate to good yields.
引用
收藏
页码：3307 / 3313
页数：7
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