Role of angiotensin II in chronic intermittent hypoxia-induced hypertension and cognitive decline

被引：11
|
作者：
Marciante, Alexandria B. [1 ,2 ,3 ]
Shell, Brent [4 ,5 ]
Farmer, George E. [6 ]
Cunningham, J. Thomas [6 ]
机构：
[1] Univ Florida, Breathing REs & THErapeut BREATHE Ctr, Gainesville, FL USA
[2] Univ Florida, Dept Phys Therapy, Gainesville, FL USA
[3] Univ Florida, McKnight Brain Inst, Gainesville, FL USA
[4] Univ Massachusetts Lowell, Zuckerberg Coll Hlth Sci, Lowell, MA USA
[5] Univ Massachusetts Lowell, Dept Biomed & Nutr Sci, Lowell, MA USA
[6] Univ North Texas Hlth Sci Ctr, Dept Physiol & Anat, Ft Worth, TX 76107 USA
来源：
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY | 2021年 / 320卷 / 04期
关键词：
angiotensin II; GABA; hypertension; SA; sleep apnea; SNA; sympathetic nerve activity; MEDIAN PREOPTIC NUCLEUS; SYMPATHETIC-NERVE ACTIVITY; BLOOD-PRESSURE ELEVATION; CHRONIC EPISODIC HYPOXIA; SUBFORNICAL ORGAN; NEURONAL-ACTIVITY; ARTERIAL-PRESSURE; NEURAL MECHANISMS; BODY-FLUID; SLEEP;
D O I：
10.1152/ajpregu.00222.2020
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Sleep apnea is characterized by momentary interruptions in normal respiration and leads to periods of decreased oxygen, or intermittent hypoxia. Chronic intermittent hypoxia is a model of the hypoxemia associated with sleep apnea and results in a sustained hypertension that is maintained during normoxia. Adaptations of the carotid body and activation of the renin-angiotensin system may contribute to the development of hypertension associated with chronic intermittent hypoxia. The subsequent activation of the brain renin-angiotensin system may produce changes in sympathetic regulatory neural networks that support the maintenance of the hypertension associated with intermittent hypoxia. Hypertension and sleep apnea not only increase risk for cardiovascular disease but are also risk factors for cognitive decline and Alzheimer?s disease. Activation of the angiotensin system could be a common mechanism that links these disorders.
引用
收藏
页码：r519 / r525
页数：7
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