Bioactive compounds from the seeds of Punica granatum (pomegranate)

被引：94
|
作者：
Wang, RF [1 ]
Xie, WD [1 ]
Zhang, Z [1 ]
Xing, DM [1 ]
Ding, Y [1 ]
Wang, W [1 ]
Ma, C [1 ]
Du, LJ [1 ]
机构：
[1] Tsinghua Univ, Dept Biol Sci & Biotechnol, Lab Pharmaceut Sci, Beijing 100084, Peoples R China
来源：
JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 12期
关键词：
D O I：
10.1021/np0498051
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new compounds, coniferyl 9-O-[beta-D-apiofuranosyl(1-->6)]-O-beta-D-glueopyranoside (1) and sinapyl 9-O-[beta-D-apiofuranosyl(1-->6)]-O-D-glucopyranoside (2), were isolated from the seeds of Punica granatum (pomegranate), together with five known compounds, 3,3'-di-O-methylellagic acid (3), 3,3',4'-tri-O-methylellagic acid (4), phenethyl rutinoside, icariside D-1, and daucosterol. The structures of 1 and 2 were elucidated by spectroscopic data analysis. Compounds 1-4 exhibited antioxidant activity, which was evaluated by measurement of low-density lipoprotein (LDL) susceptibility to oxidation and by determination in vitro of malondialdehyde (MDA) levels in the rat brain.
引用
收藏
页码：2096 / 2098
页数：3
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