The BRCA1 C-terminal domain: structure and function

被引：126
|
作者：
Huyton, T
Bates, PA
Zhang, XD
Sternberg, MJE
Freemont, PS
机构：
[1] Imperial Canc Res Fund, Biomolec Modelling Labs, London WC2A 3PX, England
[2] Univ London Imperial Coll Sci Technol & Med, Ctr Struct Biol, London SW7 2AY, England
来源：
MUTATION RESEARCH-DNA REPAIR | 2000年 / 460卷 / 3-4期
关键词：
BRCT; BRCA1; XRCC1; DNA damage repair; protein interaction module;
D O I：
10.1016/S0921-8777(00)00034-3
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The BRCA1 C-terminal region contains a duplicated globular domain termed BRCT that is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming home/hetero BRCT multimers, BRCT-non-BRCT interactions, and interactions with DNA strand breaks. The sequence and functional diversity of the BRCT superfamily suggests that BRCT domains are evolutionarily convenient interaction modules. (C) 2000 Published by Elsevier Science B.V.
引用
收藏
页码：319 / 332
页数：14
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