Recent progress in development of dopamine receptor subtype-selective agents: Potential therapeutics for neurological and psychiatric disorders

This review covers progress during 2000-2005 on the development of selective ligands targeting mainly to the five main dopamine (DA) receptors. Topics discussed include the pharmacology of dopamine receptor subtypes and the development of dopamine receptor subtype ligands. As for the latter, emphasis is on the receptor-selective ligands from D1 to D4. Generally, recent efforts in medicinal chemistry and neuropharmacology have yielded substantial numbers of compounds with activity and selectivity at each of these major DA receptors.