Pyridazinodiazepines as a high-affinity, P-2-P-3 peptidomimetic class of interleukin-1 beta-converting enzyme inhibitor

被引:48
|
作者
Dolle, RE [1 ]
Prasad, CVC [1 ]
Prouty, CP [1 ]
Salvino, JM [1 ]
Awad, MMA [1 ]
Schmidt, SJ [1 ]
Hoyer, D [1 ]
Ross, TM [1 ]
Graybill, TL [1 ]
Speier, GJ [1 ]
Uhl, J [1 ]
Miller, BE [1 ]
Helaszek, CT [1 ]
Ator, MA [1 ]
机构
[1] SANOFI WINTHROP INC,COLLEGEVILLE,PA 19426
关键词
D O I
10.1021/jm9701637
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:1941 / 1946
页数:6
相关论文
共 50 条
  • [41] Localized apoptosis and enhanced expression of p53 and interleukin-1 beta converting enzyme (ICE) proteins in human aortic atherosclerotic lesions
    Li, ZH
    Lakatta, EG
    ATHEROSCLEROSIS, 1997, 134 (1-2) : 299 - 299
  • [42] Localized apoptosis and enhanced expression of p53 and interleukin-1 beta converting enzyme (ICE) proteins in human aortic atherosclerotic lesions
    Li, ZH
    Nater, C
    CIRCULATION, 1997, 96 (08) : 2716 - 2716
  • [43] CONTRASTING INTERLEUKIN-2 BINDING-PROPERTIES OF THE ALPHA(P55) AND BETA(P70) PROTEIN SUBUNITS OF THE HUMAN HIGH-AFFINITY INTERLEUKIN-2 RECEPTOR
    LOWENTHAL, JW
    GREENE, WC
    JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 166 (04): : 1156 - 1161
  • [44] Interleukin-1 beta-converting enzyme and CPP32 are involved in ultraviolet B-induced apoptosis of SV40-transformed human keratinocytes
    Takahashi, H
    Kinouchi, M
    Iizuka, H
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 236 (01) : 194 - 198
  • [45] IDENTIFICATION OF A COMMON CLASS OF HIGH-AFFINITY RECEPTORS FOR BOTH TYPES OF PORCINE INTERLEUKIN-1 ON CONNECTIVE-TISSUE CELLS
    BIRD, TA
    SAKLATVALA, J
    NATURE, 1986, 324 (6094) : 263 - 266
  • [46] PHARMACOLOGY OF HIGH-AFFINITY RECEPTOR FOR INTERLEUKIN-1 (ALPHA AND BETA) IN MOUSE-BRAIN - MODULATION BY SYSTEMIC ADMINISTRATION OF LIPOSACCHARIDE
    BAN, E
    BARAN, D
    MILON, G
    FILLION, G
    HAOUR, F
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 183 (03) : 652 - 652
  • [47] Calcium-dependent, interleukin 1 beta-converting enzyme inhibitor-insensitive degradation of lamin B-1 and DNA fragmentation in isolated thymocyte nuclei
    McConkey, DJ
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (37) : 22398 - 22406
  • [48] CRYSTAL-STRUCTURE OF THE CYSTEINE PROTEASE INTERLEUKIN-1-BETA-CONVERTING ENZYME - A (P20/P10)(2) HOMODIMER
    WALKER, NPC
    TALANIAN, RV
    BRADY, KD
    DANG, LC
    BUMP, NJ
    FERENZ, CR
    FRANKLIN, S
    GHAYUR, T
    HACKETT, MC
    HAMMILL, LD
    HERZOG, L
    HUGUNIN, M
    HOUY, W
    MANKOVICH, JA
    MCGUINESS, L
    ORLEWICZ, E
    PASKIND, M
    PRATT, CA
    REIS, P
    SUMMANI, A
    TERRANOVA, M
    WELCH, JP
    XIONG, L
    MOLLER, A
    TRACEY, DE
    KAMEN, R
    WONG, WW
    CELL, 1994, 78 (02) : 343 - 352
  • [49] CONTRIBUTION OF A P75 INTERLEUKIN-2 BINDING PEPTIDE TO A HIGH-AFFINITY INTERLEUKIN-2 RECEPTOR COMPLEX
    TSUDO, M
    KOZAK, RW
    GOLDMAN, CK
    WALDMANN, TA
    FEDERATION PROCEEDINGS, 1987, 46 (03) : 767 - 767
  • [50] CONTRIBUTION OF A P75 INTERLEUKIN-2 BINDING PEPTIDE TO A HIGH-AFFINITY INTERLEUKIN-2 RECEPTOR COMPLEX
    TSUDO, M
    KOZAK, RW
    GOLDMAN, CK
    WALDMANN, TA
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (12) : 4215 - 4218