Effects of oxytocin and prostaglandin F2α (enzaprost) on platelet aggregation

被引：6
|
作者：
Ailamazyan, EK [1 ]
Petrishchev, NN [1 ]
Vivulanets, EV [1 ]
Maryutina, LV [1 ]
Mindukshev, IV [1 ]
Khachaturyan, AR [1 ]
机构：
[1] IP Pavlov St Petersburg State Med Univ, IM Setchenov Inst Evolut Physiol & Biochem, St Petersburg, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2002年 / 134卷 / 05期
关键词：
platelet aggregation; oxytocin; prostaglandin F-2 alpha; pregnancy; labor;
D O I：
10.1023/A:1022677927836
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effects of uterotonic agents (oxytocin and enzaprost) on platelet aggregation in pregnant and nonpregnant women were studied by low-angle light scattering. In nonpregnant women oxytocin produced different effects on ADP-induced platelet aggregation: potentiation at low (<200 nM) and inhibition at high (>400 nM) ADP concentrations. In pregnant women oxytocin did not modulate ADP-induced platelet aggregation or this effect was negligible. Enzaprost competitively inhibited ADP-induced platelet aggregation in all examined women (inhibition constant 84.8+/-25.7 nM).
引用
收藏
页码：439 / 441
页数：3
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