Thielavins W-Z7, New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004

被引：9

作者：

Han, Zhuang ^{[1
,2
]}

Li, Yong-Xin ^{[2
]}

Liu, Ling-Li ^{[2
]}

Lu, Liang ^{[2
]}

Guo, Xian-Rong ^{[3
]}

Zhang, Xi-Xiang ^{[4
]}

Zhang, Xiao-Yong ^{[5
]}

Qi, Shu-Hua ^{[5
]}

Xu, Ying ^{[2
,6
]}

Qian, Pei-Yuan ^{[2
]}

机构：

[1] Chinese Acad Sci, Inst Deep Sea Sci & Engn, 28 Luhuitou Rd, Sanya 572000, Peoples R China

[2] Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China

[3] King Abdullah Univ Sci & Technol, Imaging & Characterizat Core Lab, Thuwal 239556900, Saudi Arabia

[4] King Abdullah Univ Sci & Technol, Phys Sci & Engn, Thuwal 239556900, Saudi Arabia

[5] Chinese Acad Sci, South China Sea Inst Oceanol, Key Lab Marine Bioresources Sustainable Utilizat, 164 West Xingang Rd, Guangzhou 510301, Guangdong, Peoples R China

[6] Shenzhen Univ, Coll Life Sci, 3688 Nanhai Ave, Shenzhen 518060, Peoples R China

来源：

MARINE DRUGS | 2017年 / 15卷 / 05期

关键词：

marine-derived fungus; Thielavia sp; antifouling; Balanus (=Amphibalanus) amphitrite; thielavins; BALANUS-AMPHITRITE; INHIBITORS; SETTLEMENT; COMPOUND;

D O I：

10.3390/md15050128

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eleven new depsides-thielavins W-Z (1-4) and thielavins Z(1)-Z(7) (5-11)-and also four known thielavins-A, H, J, and K (12-15)-were isolated from the ethyl acetate extract of a marine-derived fungal strain Thielavia sp UST030930-004. All of these compounds were evaluated for antifouling activity against cyprids of the barnacle Balanus (=Amphibalanus) amphitrite. The results showed that compounds 1-3 and 6-13 were active, with EC50 values ranging from 2.95 +/- 0.59 to 69.19 +/- 9.51 mu M, respectively. The inhibitive effect of compounds 1-3 and 7 was reversible. This is the first description of the antifouling activity of thielavins against barnacle cyprids.

引用

页数：12

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