Six new ergosterols from the marine-derived fungus Rhizopus sp.

被引：49
|
作者：
Wang, Fazuo [1 ]
Fang, Yuchun [1 ]
Zhang, Min [1 ]
Lin, Aiqun [1 ]
Zhu, Anjiao [1 ]
Gu, Qianqun [1 ]
Zhu, Weiming [1 ]
机构：
[1] Ocean Univ China, Inst Marine Drugs & Food, Key Lab Marine Drugs, Chinese Minist Educ, Qingdao 266003, Peoples R China
来源：
STEROIDS | 2008年 / 73卷 / 01期
关键词：
sterols; marine-derived; fungi; structure identification; cytotoxicity;
D O I：
10.1016/j.steroids.2007.08.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Six new ergosterols, including 3 beta-hydroxyl-(22E, 24R)-ergosta-5,8,22-trien-7,15-dione (1), 3 beta-hydroxyl-(22E, 24R) -ergosta-5,8,14,22-tetraen-7-one (2), 3 beta,15 beta-dihydroxyl-(22E, 24R)-ergosta-5,8(14),22-trien-7-one (3), 3 beta,15 alpha-dihydroxyl-(22E, 24R)-ergosta-5,8(14),22-trien-7-one (4), 3 beta-hydroxyl-(22E, 24R)-ergosta-5,8(14),22-trien-7,15-dione (5), and 5 alpha,8 alpha-epidioxy-23,24(R)-dimethylcholesta-6,9(11),22-trien-3 beta-ol (6), have been isolated from the marine-derived fungus Rhizopus sp., along with four known ones (7-10). The structures of the new compounds were determined on the basis of extensive spectroscopic data. All compounds were evaluated for their cytotoxic activities on P388, A549, HL-60, and BEL-7420 cell lines by the MTT and SRB methods. (C) 2007 Published by Elsevier Inc.
引用
收藏
页码：19 / 26
页数：8
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