Phenalenones from a Marine-Derived Fungus Penicillium sp.

被引：16
|
作者：
Park, Sung Chul [1 ]
Julianti, Elin [1 ,2 ]
Ahn, Sungjin [1 ]
Kim, Donghwa [1 ]
Lee, Sang Kook [1 ]
Noh, Minsoo [1 ]
Oh, Dong-Chan [1 ]
Oh, Ki-Bong [3 ]
Shin, Jongheon [1 ]
机构：
[1] Seoul Natl Univ, Coll Pharm, Nat Prod Res Inst, San 56-1, Seoul 151742, South Korea
[2] Bandung Inst Technol, Sch Pharm, Jl Ganesha 10, Bandung 40132, Indonesia
[3] Seoul Natl Univ, Coll Agr & Life Sci, Dept Agr Biotechnol, San 56-1, Seoul 151921, South Korea
来源：
MARINE DRUGS | 2019年 / 17卷 / 03期
基金：
新加坡国家研究基金会;
关键词：
herqueinones; phenalenones; Penicillium sp; marine-derived fungi; adipogenesis; anti-angiogenesis; anti-inflammatory; SCLERODERRIS CANKER FUNGUS; HERQUEINONE; METABOLITES; BIOSYNTHESIS; ANGIOGENESIS; ATROVENETIN; ACETYLATION; INHIBITORS; ALCOHOLS; PHENOLS;
D O I：
10.3390/md17030176
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Six new phenalenone derivatives (1-6), along with five known compounds (7-11) of the herqueinone class, were isolated from a marine-derived fungus Penicillium sp. The absolute configurations of these compounds were assigned based on chemical modifications and their specific rotations. 4-Hydroxysclerodin (6) and an acetone adduct of a triketone (7) exhibited moderate anti-angiogenetic and anti-inflammatory activities, respectively, while ent-peniciherqueinone (1) and isoherqueinone (9) exhibited moderate abilities to induce adipogenesis without cytotoxicity.
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页数：16
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