Phenalenones from a Marine-Derived Fungus Penicillium sp.

被引：16

作者：

Park, Sung Chul ^{[1
]}

Julianti, Elin ^{[1
,2
]}

Ahn, Sungjin ^{[1
]}

Kim, Donghwa ^{[1
]}

Lee, Sang Kook ^{[1
]}

Noh, Minsoo ^{[1
]}

Oh, Dong-Chan ^{[1
]}

Oh, Ki-Bong ^{[3
]}

Shin, Jongheon ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Nat Prod Res Inst, San 56-1, Seoul 151742, South Korea

[2] Bandung Inst Technol, Sch Pharm, Jl Ganesha 10, Bandung 40132, Indonesia

[3] Seoul Natl Univ, Coll Agr & Life Sci, Dept Agr Biotechnol, San 56-1, Seoul 151921, South Korea

来源：

MARINE DRUGS | 2019年 / 17卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

herqueinones; phenalenones; Penicillium sp; marine-derived fungi; adipogenesis; anti-angiogenesis; anti-inflammatory; SCLERODERRIS CANKER FUNGUS; HERQUEINONE; METABOLITES; BIOSYNTHESIS; ANGIOGENESIS; ATROVENETIN; ACETYLATION; INHIBITORS; ALCOHOLS; PHENOLS;

D O I：

10.3390/md17030176

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Six new phenalenone derivatives (1-6), along with five known compounds (7-11) of the herqueinone class, were isolated from a marine-derived fungus Penicillium sp. The absolute configurations of these compounds were assigned based on chemical modifications and their specific rotations. 4-Hydroxysclerodin (6) and an acetone adduct of a triketone (7) exhibited moderate anti-angiogenetic and anti-inflammatory activities, respectively, while ent-peniciherqueinone (1) and isoherqueinone (9) exhibited moderate abilities to induce adipogenesis without cytotoxicity.

引用

页数：16

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