Synthesis of nitroimidazole derived oxazolidinones as antibacterial agents

被引：21

作者：

Varshney, Vandana ^{[1
]}

Mishra, Nripendra N. ^{[2
]}

Shukla, Praveen K. ^{[2
]}

Sahu, Devi P. ^{[1
]}

机构：

[1] Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226001, Uttar Pradesh, India

[2] Cent Drug Res Inst, Fermentat Technol Div, Lucknow 226001, Uttar Pradesh, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 02期

关键词：

Oxazolidinone; Nitroimidazoles; Antibacterial; Linezolid; LINEZOLID-RESISTANT;

D O I：

10.1016/j.ejmech.2009.11.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of N-alkylated derivatives of nitroimidazolyl oxazolidinones 6a-i with various substituent at N-1 position of the nitroimidazole were synthesized and their in-vitro antibacterial activities were evaluated against several Gram-positive and Gram-negative bacteria. The 6a was found to be most potent compound in the series with MIC at 0.097 mu g/mL against Bacillus cereus MTCC 430.). Both 6a and 6f did not exhibit any toxicity towards mammalian cell L929. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：661 / 666

页数：6

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