Synthesis of nitroimidazole derived oxazolidinones as antibacterial agents

被引：21

作者：

Varshney, Vandana ^{[1
]}

Mishra, Nripendra N. ^{[2
]}

Shukla, Praveen K. ^{[2
]}

Sahu, Devi P. ^{[1
]}

机构：

[1] Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226001, Uttar Pradesh, India

[2] Cent Drug Res Inst, Fermentat Technol Div, Lucknow 226001, Uttar Pradesh, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 02期

关键词：

Oxazolidinone; Nitroimidazoles; Antibacterial; Linezolid; LINEZOLID-RESISTANT;

D O I：

10.1016/j.ejmech.2009.11.009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of N-alkylated derivatives of nitroimidazolyl oxazolidinones 6a-i with various substituent at N-1 position of the nitroimidazole were synthesized and their in-vitro antibacterial activities were evaluated against several Gram-positive and Gram-negative bacteria. The 6a was found to be most potent compound in the series with MIC at 0.097 mu g/mL against Bacillus cereus MTCC 430.). Both 6a and 6f did not exhibit any toxicity towards mammalian cell L929. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：661 / 666

页数：6

共 50 条

[1] Facile Synthesis of Oxazolidinones as Potential Antibacterial Agents
Els, Secret P.
Govender, Kimberleigh B.
Sokhela, Mxolisi K.
Bhatt, Nilay
Reddy, Nakita
Kruger, Hendrik G.
Arvidsson, Per I.
Gunosewoyo, Hendra
Govender, Thavendran
Naicker, Tricia
CHEMISTRYOPEN, 2025,
[2] Oxazolidinones: New antibacterial agents
Ford, CW
Hamel, JC
Stapert, D
Moerman, JK
Hutchinson, DK
Barbachyn, MR
Zurenko, GE
TRENDS IN MICROBIOLOGY, 1997, 5 (05) : 196 - 200
[3] Synthesis and evaluation of urea and thiourea derivatives of oxazolidinones as antibacterial agents
Aaramadaka, Sunil Kumar Reddy
Guha, Mrinal Kanthi
Prabhu, Ganesh
Kini, Suvarna Ganesh.
Vijayan, Magesh
CHEMICAL & PHARMACEUTICAL BULLETIN, 2007, 55 (02) : 236 - 240
[4] Novel Mannich ketones of oxazolidinones as antibacterial agents
Srivastava, BK
Kapadnis, PB
Pandya, P
Lohray, VB
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2004, 39 (11) : 989 - 992
[5] Synthesis and biological evaluation of novel benzoxazinyl-oxazolidinones as potential antibacterial agents
Guo, Bin
Fan, Houxing
Xin, Qisheng
Chu, Wenjing
Wang, Hui
Yang, Yushe
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (13) : 3697 - 3699
[6] SOME NITROIMIDAZOLE DERIVATIVES AS POSSIBLE ANTIBACTERIAL AGENTS
DEMIRAYAK, S
KIRAZ, N
FARMACO, 1993, 48 (03): : 443 - 446
[7] Computational approach to drug design for oxazolidinones as antibacterial agents
Li, Yun
Wei, Dong-Qing
Gao, Wei-Na
Gao, Hui
Liu, Bing-Ni
Huang, Chang-Jiang
Xu, Wei-Ren
Liu, Deng-Ke
Chen, Hai-Feng
Chou, Kuo-Chen
MEDICINAL CHEMISTRY, 2007, 3 (06) : 576 - 582
[8] Synthesis and antibacterial evaluation of isoxazolinyl oxazolidinones: Search for potent antibacterial
Varshney, Vandana
Mishra, Nripendra N.
Shukla, Praveen K.
Sahu, Devi P.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (13) : 3573 - 3576
[9] Synthesis and antibacterial activity of substituted oxotriazolylphenyl Oxazolidinones
Liu, Jidong
He, Baoyuan
Yu, Aizhen
Zhou, Weicheng
CHEMICAL BIOLOGY & DRUG DESIGN, 2007, 70 (01) : 65 - 69
[10] Synthesis and in vitro antibacterial activities of novel oxazolidinones
Srivastava, Brijesh Kumar
Jain, Mukul R.
Solanki, Manish
Soni, Rina
Valani, Darshan
Gupta, Sunil
Mishra, Bhupendra
Takale, Vijay
Kapadnis, Prashant
Patel, Harilal
Pandya, Purvi
Patel, Jayendra Z.
Patel, Pankaj R.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2008, 43 (04) : 683 - 693

← 1 2 3 4 5 →