Association between embB codon 306 mutations and drug resistance in Mycobacterium tuberculosis

被引：43
|
作者：
Shen, Xin
Shen, Guo-miao
Wu, Jie
Gui, Xiao-hong
Li, Xia
Mei, Jian
DeRiemer, Kathryn
Gao, Qian
机构：
[1] Shanghai Med Coll, Key Lab Med Mol Virol, Shanghai 200032, Peoples R China
[2] Inst Med Microbiol, Shanghai 200032, Peoples R China
[3] Inst Biomed Sci, Shanghai 200032, Peoples R China
[4] Fudan Univ, Shanghai 200032, Peoples R China
[5] Shanghai Municipal Ctr Dis Control & Prevent, Dept TB Control, Shanghai, Peoples R China
[6] Univ Calif Davis, Sch Med, Davis, CA 95616 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 07期
关键词：
D O I：
10.1128/AAC.01516-06
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
embB306 mutants were detected in both ethambutol (EMB)-resistant and EMB-susceptible strains of Mycobacterium tuberculosis. Multidrug-resistant (MDR) strains had a higher proportion of embB306 mutants than non-MDR strains (odds ratio, 6.78; P < 0.001). The embB306 locus is a candidate marker for rapid detection of MDR and extremely drug resistant tuberculosis.
引用
收藏
页码：2618 / 2620
页数：3
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