Anterior Cingulate Volumetric Alterations in Treatment-Naive Adults With ADHD A Pilot Study

被引：48
|
作者：
Makris, Nikos [1 ,3 ]
Seidman, Larry J. [2 ,9 ]
Valera, Eve M.
Biederman, Joseph [5 ,6 ]
Monuteaux, Michael C. [5 ,6 ]
Kennedy, David N.
Caviness, Verne S., Jr.
Bush, George
Crum, Katherine
Brown, Ariel B. [3 ,7 ,8 ]
Faraone, Stephen V. [4 ]
机构：
[1] Massachusetts Gen Hosp, Ctr Morphometr Anal, Charlestown, MA 02129 USA
[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Psychiat, Cambridge, MA 02138 USA
[3] Boston Univ, Sch Med, Boston, MA 02215 USA
[4] SUNY Upstate Med Univ, Syracuse, NY USA
[5] Massachusetts Gen Hosp, ADHD, Charlestown, MA 02129 USA
[6] Massachusetts Gen Hosp, Clin & Res Programs Pediat Psychopharmacol, Charlestown, MA 02129 USA
[7] Massachusetts Gen Hosp, Pediat Psychopharmacol Clin, Charlestown, MA 02129 USA
[8] Massachusetts Gen Hosp, Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
[9] Massachusetts Gen Hosp, Boston, MA 02114 USA
来源：
JOURNAL OF ATTENTION DISORDERS | 2010年 / 13卷 / 04期
基金：
美国国家卫生研究院;
关键词：
ADHD; treatment-naive ADHD; ACC; volumetry; morphometry; MRI; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY DISORDER; MOTOR CONTROL; CHILDREN; MRI; CORTEX; ABNORMALITIES; BRAIN; ADOLESCENTS; NETWORKS;
D O I：
10.1177/1087054709351671
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
Objective: We sought to examine preliminary results of brain alterations in anterior cingulate cortex (ACC) in treatment-naive adults with ADHD. The ACC is a central brain node for the integration of cognitive control and allocation of attention, affect and drive. Thus its anatomical alteration may give rise to impulsivity, hyperactivity and inattention, which are cardinal behavioral manifestations of ADHD. Method: Segmentation and parcellation of the ACC was performed on controls (n = 22), treated (n = 13) and treatment-naive adults with ADHD (n = 13). Results: There was a 21% volume reduction in the left ACC of the treatment-naive group relative to the control group. Also, there was a 23% volume reduction in the right ACC of the treated group relative to the control group. Conclusion: These results raise the possibility that in ADHD there are volumetric deficits persistent into adulthood, that are independent of medical treatment. (J. of Att. Dis. 2010; 13(4) 407-413)
引用
收藏
页码：407 / 413
页数：7
相关论文
共 50 条
  • [21] Common and distinct brain functional alterations in pharmacotherapy treatment-naive female borderline personality disorder patients with and without auditory verbal hallucinations: a pilot study
    Zhuo, Chuanjun
    Ji, Feng
    Lin, Xiao
    Tian, Hongjun
    Wang, Lina
    Xu, Yong
    Wang, Wenqiang
    Zhong, Baoliang
    Lin, Xiaodong
    EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2021, 271 (06) : 1149 - 1157
  • [22] Dorsolateral pre-frontal and anterior cingulate abnormalities in adults with ADHD assessed with structural MRI
    Seidman, LJ
    BIOLOGICAL PSYCHIATRY, 2006, 59 (08) : 192S - 193S
  • [23] Atazanavir approved for treatment-naive HIV-1-infected adults
    不详
    BRITISH JOURNAL OF HOSPITAL MEDICINE, 2009, 70 (01) : 8 - 8
  • [24] Volumetric magnetic resonance imaging study of the anterior cingulate gyrus in schizotypal disorder
    Takahashi, T
    Suzuki, M
    Kawasaki, Y
    Kurokawa, K
    Hagino, H
    Yamashita, I
    Zhou, SY
    Nohara, S
    Nakamura, K
    Seto, H
    Kurachi, M
    EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE, 2002, 252 (06) : 268 - 277
  • [25] AFLIBERCEPT IN TREATMENT-NAIVE PATIENTS WITH NEOVASCULAR AGE-RELATED MACULAR DEGENERATION: PROSPECTIVE PILOT STUDY
    Udaondo, Patricia
    Garcia-Delpech, Salvador
    Salom, David
    Hervas-Ontiveros, Ana
    Diaz-Cespedes, Ricardo
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (12)
  • [26] Evaluation of marker of endothelial dysfunction and regeneration in HIV-positive treatment-naive patients: a pilot study
    Cesari, F.
    Cerini, G.
    Gori, A. M.
    Rogolino, A.
    Martinelli, C.
    Carocci, A.
    Corsi, P.
    Leoncini, F.
    Gensini, G. F.
    Abbate, R.
    EUROPEAN HEART JOURNAL, 2010, 31 : 825 - 825
  • [27] Volumetric magnetic resonance imaging study of the anterior cingulate gyrus in schizotypal disorder
    Tsutomu Takahashi
    Michio Suzuki
    Yasuhiro Kawasaki
    Kenzo Kurokawa
    Hirofumi Hagino
    Ikiko Yamashita
    Shi-Yu Zhou
    Shigeru Nohara
    Kazue Nakamura
    Hikaru Seto
    Masayoshi Kurachi
    European Archives of Psychiatry and Clinical Neuroscience, 2002, 252 : 268 - 277
  • [28] Effect of antipsychotics on pituitary gland volume in treatment-naive first-episode schizophrenia: A pilot study
    MacMaster, Frank P.
    El-Sheikh, Rhonda
    Upadhyaya, Ameet R.
    Nutche, Jeffrey
    Rosenberg, David R.
    Keshavan, Matcheri
    SCHIZOPHRENIA RESEARCH, 2007, 92 (1-3) : 207 - 210
  • [29] Longitudinal predictors of addictions treatment utilization in treatment-naive adults with alcohol use disorders
    Ilgen, Mark A.
    Price, Amanda M.
    Burnett-Zeigler, Inger
    Perron, Brian
    Islam, Khairul
    Bohnert, Amy S. B.
    Zivin, Kara
    DRUG AND ALCOHOL DEPENDENCE, 2011, 113 (2-3) : 215 - 221
  • [30] LONGITUDINAL PREDICTORS OF ADDICTIONS TREATMENT UTILIZATION IN TREATMENT-NAIVE ADULTS WITH ALCOHOL USE DISORDERS
    Ilgen, M. A.
    Burnett-Zeigler, I.
    Price, A. M.
    Islam, K.
    Bohnert, A.
    Zivin, K.
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2010, 34 (06) : 230A - 230A
12345