Syntheses of optically pure, conformationally constrained, and highly hydrophobic unusual amino acids: 2-amino-3, 3-diarylpropionic acids

被引：15

作者：

Lin, J

Liao, S

Hruby, VJ ^{[1
]}

机构：

[1] Univ Arizona, Dept Chem, Tucson, AZ 85721 USA

[2] Yunnan Univ, Dept Appl Chem, Kunming 650091, Peoples R China

[3] Pfizer Inc, Med Chem, St Louis, MO 63167 USA

来源：

JOURNAL OF PEPTIDE RESEARCH | 2005年 / 65卷 / 01期

关键词：

aromatic amino acids; asymmetric synthesis; conformationally constrained amino acids;

D O I：

10.1111/j.1399-3011.2004.00194.x

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of optically pure, conformationally constrained, and highly hydrophobic unusual aromatic amino acids, 2-amino-3,3-diarylpropionic acids, were synthesized via asymmetric 1,4-Michael addition reaction/azidation reactions in seven steps with overall yields of 20-30%.

引用

页码：105 / 112

页数：8

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