External Auditory Canal and Middle Ear Relapse of Acute Promyelocytic Leukemia Treated With Arsenic Trioxide Case Report and Review of the Literature

被引：8

作者：

Sampaio Lafayette, Thereza Christina ^{[1
]}

Coser, Virginia Maria ^{[1
]}

Brule, Alice Odette ^{[1
]}

Coser, Pedro Luis ^{[2
]}

Pereira, Waldir Veiga ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Dept Pediat Hematol Oncol, BR-97119900 Santa Maria, RS, Brazil

[2] Univ Fed Santa Maria, Dept Otorrinolaringol, Serv Otorrinolaringol, BR-97119900 Santa Maria, RS, Brazil

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2010年 / 32卷 / 03期

关键词：

acute promyelocytic leukemia; extramedullary relapse; arsenic trioxide; TRANS-RETINOIC ACID; EXTRAMEDULLARY INVOLVEMENT;

D O I：

10.1097/MPH.0b013e3181cf7ef3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Extramedullary involvement occurs infrequently in acute promyelocytic leukemia and is said to be more common after treatment with all-trans retinoic acid. We describe a 9-year-old girl who had an isolated external auditory canal and middle ear relapse after treatment with all-trans retinoic acid and chemotherapy. A patient with cytogenetically and molecularly confirmed acute promyelocytic leukemia developed isolated extramedullary relapse in the auditory canal and middle ear 4 years and 9 months after initial diagnosis, while in hematologic and molecular remission, successfully treated with arsenic trioxide alone.

引用

页码：229 / 232

页数：4

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