TAP-independent antigen presentation on MHC class I molecules: lessons from Epstein-Barr virus

被引：46
|
作者：
Lautscham, G
Rickinson, A
Blake, N
机构：
[1] Univ Liverpool, Dept Med Microbiol, Liverpool L69 3GA, Merseyside, England
[2] Univ Birmingham, Canc Res UK, Inst Canc Studies, Birmingham B15 2TT, W Midlands, England
[3] Max Delbruck Ctr Mol Med, D-13125 Berlin, Germany
来源：
MICROBES AND INFECTION | 2003年 / 5卷 / 04期
关键词：
Epstein-Barr virus (EBV); MHC class I processing; TAP independence; hydrophobicity;
D O I：
10.1016/S1286-4579(03)00031-5
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
For recognition by CD8(+) lymphocytes, peptides derived from cytosolically processed antigen need to access MHC class I molecules en route to the target cell surface. This normally requires peptide transport into the endoplasmic reticulum via the transporter associated with antigen presentation (TAP) complex. However, as recent work with Epstein-Barr virus illustrates, TAP-independent presentation pathways also exist and are growing in number. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码：291 / 299
页数：9
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