The potential role of periovarian fat and leptin in initiation of puberty in the immature rat

被引:12
|
作者
Cannady, WE [1 ]
Brann, DW [1 ]
Mahesh, VB [1 ]
机构
[1] Med Coll Georgia, Dept Physiol & Endocrinol, Augusta, GA 30912 USA
关键词
leptin; ovary; periovarian fat; estradiol; puberty;
D O I
10.1038/sj.ijo.0801307
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Twenty-four-day old female rats were injected with 25 mu g recombinant leptin twice daily for 24, 48, 72, or 93 h, Periovarian fat contained significantly greater amounts of aromatase mRNA at 72 and 93 h and estradiol at 72 h after leptin treatment as compared to the ovary. On the other hand, there was an increase in testosterone at 72 h and progesterone at 72 and 93 h after leptin in the ovary as compared to periovarian fat. Cholesterol side chain cleavage and 17 alpha-hydroxylase mRNA were found only in the ovary and not periovarian fat. Thus, periovarian fat has a greater capacity to synthesize estrogen than the ovary in the immature rat and adipose tissue may serve as the primary source of estrogen in the prepubertal period which results in the onset of puberty.
引用
收藏
页码:S146 / S147
页数:2
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