Design and delivery of camplatin to overcome cisplatin drug resistance

被引：32
|
作者：
Qi, Ruogu [1 ,2 ]
Xiao, Haihua [1 ,2 ]
Wu, Suhong [1 ,2 ]
Li, Yuxin [3 ]
Zhang, Yu [3 ]
Jing, Xiabin [1 ]
机构：
[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] NE Normal Univ, Natl Engn Lab Druggable Gene & Prot Screening, Changchun 130024, Peoples R China
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2015年 / 3卷 / 02期
基金：
中国国家自然科学基金;
关键词：
OVARIAN-CANCER; CELLS; CARBOPLATIN; EFFICACY; PRODRUGS; BCL-2;
D O I：
10.1039/c4tb01146e
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Camplatin, a prodrug formed via coining camphoric anhydride and cisplatin, was delivered in biodegradable nanoparticles. This camphoric acid and cisplatin co-delivery system exhibited enhanced anticancer activity compared to cisplatin and has successfully overcome cisplatin drug resistance.
引用
收藏
页码：176 / 179
页数：4
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