Biogenesis and Function of the NGF/TrkA Signaling Endosome

被引：100

作者：

Marlin, M. Caleb ^{[1
]}

Li, Guangpu ^{[1
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Dept Biochem & Mol Biol, Oklahoma City, OK 73190 USA

来源：

INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY, VOL 314 | 2015年 / 314卷

关键词：

NERVE GROWTH-FACTOR; TRK NEUROTROPHIN RECEPTORS; NGF-MEDIATED FUNCTIONS; SYMPATHETIC NEURONS; NEURITE OUTGROWTH; PC12; CELLS; RECYCLING ENDOSOMES; AXONAL MICROTUBULES; CYTOPLASMIC DYNEIN; MEMBRANE-PROTEINS;

D O I：

10.1016/bs.ircmb.2014.10.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Target-derived neurotrophin nerve growth factor (NGF) and its receptor TrkA are well known for retrograde signaling to promote survival and innervation of sympathetic and sensory neurons. In recent years, the signaling endosome model has been used to describe the sustained NGF/TrkA retrograde signaling as a process of endocytosis and retrograde transport of NGF/TrkA-containing endosomes from the axon terminal to the cell body for activation of NGF-inducible gene expression responsible for neuronal survival and development. Here, we review the biogenesis and function of NGF, TrkA, and the signaling endosome and discuss possible roles of Rab GTPases in the biogenesis and trafficking of signaling endosomes.

引用

页码：239 / 257

页数：19

共 50 条

[31] Characterization of an NGF-P-TrkA retrograde-signaling complex and age-dependent regulation of TrkA phosphorylation in sympathetic neurons
Tsui-Pierchala, BA
Ginty, DD
JOURNAL OF NEUROSCIENCE, 1999, 19 (19): : 8207 - 8218
[32] The Intersection of NGF/TrkA Signaling and Amyloid Precursor Protein Processing in Alzheimer's Disease Neuropathology
Canu, Nadia
Amadoro, Giuseppina
Triaca, Viviana
Latina, Valentina
Sposato, Valentina
Corsetti, Veronica
Severini, Cinzia
Ciotti, Maria Teresa
Calissano, Pietro
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 18 (06)
[33] Sprouty4 Is an Endogenous Negative Modulator of TrkA Signaling and Neuronal Differentiation Induced by NGF
Alsina, Fernando C.
Irala, Dolores
Fontanet, Paula A.
Hita, Francisco J.
Ledda, Fernanda
Paratcha, Gustavo
PLOS ONE, 2012, 7 (02):
[34] NGF-TrkA Signaling by Sensory Nerves Coordinates the Vascularization and Ossification of Developing Endochondral Bone
Tomlinson, Ryan E.
Li, Zhi
Zhang, Qian
Goh, Brian C.
Li, Zhu
Thorek, Daniel L. J.
Rajbhandari, Labchan
Brushart, Thomas M.
Minichiello, Liliana
Zhou, Fengquan
Venkatesan, Arun
Clemens, Thomas L.
CELL REPORTS, 2016, 16 (10): : 2723 - 2735
[35] Electroacupuncture improves neurogenic bladder dysfunction through activation of NGF/TrkA signaling in a rat model
Zhang, Tong
Yu, Jiafeng
Huang, Zongqiang
Wang, Gang
Zhang, Runhe
JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (06) : 9900 - 9905
[36] NGF-TrkA signaling in sensory nerves is required for skeletal adaptation to mechanical loads in mice
Tomlinson, Ryan E.
Li, Zhi
Li, Zhu
Minichiello, Liliana
Riddle, Ryan C.
Venkatesan, Arun
Clemens, Thomas L.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 114 (18) : E3632 - E3641
[37] FBXO22 Mediates the NGF/TRKA Signaling Pathway in Bone Metastases in Prostate Cancer
Zhang, Yuehua
Li, Wen
Guo, Shenghu
Wu, Zheng
Zhang, Lei
Liu, Ya
Li, Xing
Guo, Xiaojin
Cao, Jing
Yang, Chunwang
Wang, Zhiyu
AMERICAN JOURNAL OF PATHOLOGY, 2023, 193 (09): : 1248 - 1266
[38] Multivesicular Endosome Biogenesis in the Absence of ESCRTs
Stuffers, Susanne
Wegner, Catherine Sem
Stenmark, Harald
Brech, Andreas
TRAFFIC, 2009, 10 (07) : 925 - 937
[39] Lipid Sorting and Multivesicular Endosome Biogenesis
Bissig, Christin
Gruenberg, Jean
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2013, 5 (10):
[40] Detection of nerve growth factor (NGF) and its specific receptor (TrkA) in ejaculated bovine sperm, and the effects of NGF on sperm function
Li, C.
Sun, Y.
Yi, K.
Ma, Y.
Sun, Y.
Zhang, W.
Zhou, X.
THERIOGENOLOGY, 2010, 74 (09) : 1615 - 1622

← 1 2 3 4 5 →