Clavaminols A-F, novel cytotoxic 2-amino-3-alkanols from the ascidian Clavelina phlegraea

被引：46

作者：

Aiello, Anna

Fattorusso, Ernesto

Giordano, Antonella

Menna, Marialuisa

Navarrete, Carmen

Munoz, Eduardo

机构：

[1] Univ Naples Federico II, Dipartimento Chim Sostanze Nat, I-80131 Naples, Italy

[2] Univ Cordoba, Dept Biol Celular Fisiol & Inmunol, Cordoba 14004, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 08期

关键词：

marine natural products; amino alcohols; cytotoxic compounds; ascidians;

D O I：

10.1016/j.bmc.2007.02.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The chemical investigation of the Mediterranean ascidian Clavelina phlegraea has led to the isolation of six new 2-amino-3-alkanol derivatives, clavaminols A-F (1-6). Their stereo structures were established by analysis of spectroscopic data and chemical conversion. Clavaminols A, B, C, and F were tested for their cytotoxic and pro-apoptotic properties and clavaminol A was shown to be the more potent cytotoxic compound of this series inducing cell death through activation of the apoptotic machinery. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：2920 / 2926

页数：7

共 50 条

[21] 1ST SYNTHESIS OF THE CYTOTOXIC AND ANTIFUNGAL C-14 AMINE (2S,3E,5Z)-2-AMINO-3,5,13-TETRADECATRIENE ISOLATED FROM THE NEW-ZEALAND ASCIDIAN PSEUDODISTOMA-NOVAEZELANDIAE
ENDERS, D
FINKAM, M
LIEBIGS ANNALEN DER CHEMIE, 1993, (05): : 551 - 555
[22] A novel and convenient synthesis of 3-amino-2H-1,2,4-triazoles from isoselenocyanates and hydrazine hydrate
Li, Xue
Peng, Zhixiang
Zhang, Yuanyuan
Wang, Jiangwei
Gan, Bin
Xie, Yuanyuan
JOURNAL OF CHEMICAL RESEARCH, 2018, (05) : 255 - 259
[23] Synthesis of novel fused thienodiazaphosphorine derivatives from 2-amino-3-cyanothiophenes and Lawesson's reagent
Khalladi, Khaoula
Touil, Soufiane
JOURNAL OF SULFUR CHEMISTRY, 2012, 33 (01) : 27 - 32
[24] Preparation, Spectral Characterization, Antimicrobial and Cytotoxic Studies of some Transition Metal Nanocomplexes of a Novel Azo Derivative Formed from 2-Amino -5- Methylthiazol
Majhool, Suha Hassan
Waheeb, Azal Shakir
Awad, Masar Ali
JOURNAL OF NANOSTRUCTURES, 2024, 14 (02) : 411 - 426
[25] NOVEL SYNTHESES OF HETEROCYCLES FROM ALPHA-KETONITRILES .3. 3-AMINO-4-ARYL-1,2,5-OXADIAZOLES
LAKHAN, R
SINGH, OP
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1987, 26 (07): : 690 - 692
[26] 2-PROPYL-4-ETHYL-3-NITROSOOXAZOLIDINE, A NOVEL PRODUCT FROM THE NITROUS ACID DEAMINATION OF 2-AMINO-1-BUTANOL
NACE, HR
GOLLIS, MH
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1952, 74 (20) : 5189 - 5192
[27] Access to New Cytotoxic Quinone-Amino Acid Conjugates Linked through A Vinylic Spacer from 2-Acylnaphthoquinones and Methyl 3-Aminocrotonate
Valderrama, Jaime A.
Garrido, Joel
Delgado, Virginia
Benites, Julio
Theoduloz, Cristina
MOLECULES, 2017, 22 (12):
[28] Synthesis of Functionally Substituted Pyrrolo[2,3-g]- and Pyrrolo[3,2-f]quinolines from 5-Amino-2-phenyl- and 5-Amino-1-methyl-2-phenylindoles
S. A. Yamashkin
G. A. Romanova
I. S. Romanova
M. A. Yurovskaya
Chemistry of Heterocyclic Compounds, 2003, 39 (9) : 1188 - 1196
[29] NOVEL SYNTHESIS OF 3-(N-SUBSTITUTED AMINO)-1-ISOINDOLENONES FROM 2-CYANOBENZALDEHYDE WITH AMINES
SATO, R
SENZAKI, T
GOTO, T
SAITO, M
CHEMISTRY LETTERS, 1984, (09) : 1599 - 1602
[30] Nostocyclin, a novel 3-amino-6-hydroxy-2-piperidone-containing cyclic depsipeptide from the cyanobacterium Nostoc sp
Kaya, K
Sano, T
Beattie, KA
Codd, GA
TETRAHEDRON LETTERS, 1996, 37 (37) : 6725 - 6728

← 1 2 3 4 5 →