VARIANTS IN THE GENE GPBAR1 ENCODING THE BILE ACID RECEPTOR TGR5 DETERMINE PROGRESSION OF LIVER FIBROSIS IN PEDIATRIC AUTOIMMUNE LIVER DISEASE AND IN MURINE SCLEROSING CHOLANGITIS

被引：0

作者：

Matuschek, Nelson ^{[1
]}

Kudira, Ramesh ^{[2
]}

Mullen, Mary ^{[2
]}

Singh, Ruchi ^{[3
]}

Lam, Simon ^{[2
]}

Adachi, Senna ^{[2
]}

Maynor, Sean ^{[3
]}

Karns, Rebekah ^{[2
]}

Namjou, Bahram ^{[4
]}

Sheridan, Rachel M. ^{[5
]}

Miethke, Alexander G. ^{[2
]}

机构：

[1] Cincinnati Childrens Hosp Med Ctr, Pediat Gastroenterol, Cincinnati, OH 45229 USA

[2] Cincinnati Childrens Hosp Med Ctr, Div Pediat Gastroenterol Hepatol & Nutr, Cincinnati, OH 45229 USA

[3] Cincinnati Childrens Hosp Med Ctr, Gastroenterol Hepatol & Nutr, Cincinnati, OH 45229 USA

[4] Cchmc, CAGE, Cincinnati, OH USA

[5] Cincinnati Childrens Hosp Med Ctr, Div Pathol & Lab Med, Cincinnati, OH 45229 USA

来源：

HEPATOLOGY | 2019年 / 70卷

关键词：

D O I：

暂无

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

1413

引用

页码：854A / 855A

页数：2

共 32 条

[21] Activation of G-protein-coupled bile acid receptor Gpbar1 (TGR5) inhibits degradation of type II collagen and aggrecan in human chondrocytes
Zhuo, Wenkun
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EUROPEAN JOURNAL OF PHARMACOLOGY, 2019, 856
[22] Serum bile acid species are associated with liver fibrosis and clinical disease progression in patients with primary sclerosing cholangitis
Trauner, Michael
Kowdley, Kris V.
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Xu, Jun
Wang, Ya
Chen, Guang
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Thorburn, Douglas
Levy, Cynthia
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JOURNAL OF HEPATOLOGY, 2020, 73 : S482 - S483
[23] Mogrol stimulates G-protein-coupled bile acid receptor 1 (GPBAR1/TGR5) and insulin secretion from pancreatic β-cells and alleviates hyperglycemia in mice
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Urushizaki, Hiroki
Shinmori, Yoh
Onishi, Teruaki
Yotsumoto, Yusuke
Ito, Yuta
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SCIENTIFIC REPORTS, 2024, 14 (01)
[24] Mogrol stimulates G-protein-coupled bile acid receptor 1 (GPBAR1/TGR5) and insulin secretion from pancreatic β-cells and alleviates hyperglycemia in mice
Chisato Tanaka
Naoki Harada
Yoshiaki Teraoka
Hiroki Urushizaki
Yoh Shinmori
Teruaki Onishi
Yusuke Yotsumoto
Yuta Ito
Tomoya Kitakaze
Takashi Inui
Yuji Murata
Hiroshi Inui
Ryoichi Yamaji
Scientific Reports, 14
[25] The G-Protein-Coupled Bile Acid Receptor Gpbar1 (TGR5) Inhibits Gastric Inflammation Through Antagonizing NF-κB Signaling Pathway
Guo, Cong
Qi, Hui
Yu, Yingjie
Zhang, Qiqi
Su, Jia
Yu, Donna
Huang, Wendong
Chen, Wei-Dong
Wang, Yan-Dong
FRONTIERS IN PHARMACOLOGY, 2015, 6
[26] Does the bile acid receptor TGR5 play a role in Kupffer cell response during Alcoholic Liver Disease?
Spatz, M.
Ciocan, D.
Neuza, F.
Rainteau, D.
Humbert, L.
Hugot, C.
Wrzosek, L.
Virginie, P.
Ferrere, G.
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Tordjmann, T.
Doulcier, A. -M. C.
JOURNAL OF HEPATOLOGY, 2018, 68 : S607 - S607
[27] Aberrant DNA Methylation of G-protein-coupled Bile Acid Receptor Gpbar1 (TGR5) is a Potential Biomarker for Hepatitis B Virus Associated Hepatocellular Carcinoma
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Mu, Nan-Nan
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Ji, Xiang-Fen
Dou, Cheng-Yun
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INTERNATIONAL JOURNAL OF MEDICAL SCIENCES, 2014, 11 (02): : 164 - 171
[28] THE G-PROTEIN-COUPLED BILE ACID RECEPTOR TGR5 (GPBAR1) IS EXPRESSED IN BOTH MUCOSA AND MUSCLE TISSUE FROM HUMAN LOWER ESOPHAGEAL SPHINCTER (LES)
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Smith, Adaline C.
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GASTROENTEROLOGY, 2020, 158 (06) : S313 - S314
[29] RETRACTED: Deficiency of G-Protein-Coupled Bile Acid Receptor Gpbar1 (TGR5) Enhances Chemically Induced Liver Carcinogenesis (Retracted article. See vol. 58, pg. 1194, 2013)
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Yu, Donna
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HEPATOLOGY, 2013, 57 (02) : 656 - 666
[30] The G-protein-coupled bile acid receptor Gpbar1 (TGR5) suppresses gastric cancer cell proliferation and migration through antagonizing STAT3 signaling pathway
Guo, Cong
Su, Jia
Li, Zhijun
Xiao, Rui
Wen, Jianxun
Li, Yanyan
Zhang, Meng
Zhang, Xueting
Yu, Donna
Huang, Wendong
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Wang, Yan-Dong
ONCOTARGET, 2015, 6 (33) : 34402 - 34413

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