Organization of the interferon-inducible 2′,5′-oligoadenylate-dependent ribonuclease L (RNase L) gene of mouse

被引：2

作者：

Pandey, Mitali ^{[1
]}

Rath, Pramod C. ^{[1
]}

机构：

[1] Jawaharlal Nehru Univ, Sch Life Sci, Mol Biol Lab, New Delhi 110067, India

来源：

MOLECULAR BIOLOGY REPORTS | 2007年 / 34卷 / 02期

关键词：

antiviral response; interferon; murine RNase L; gene structure; 5'-flanking DNA;

D O I：

10.1007/s11033-006-9020-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interferons (IFNs) induce a 2',5'-oligoadenylate (2-5A)-dependent ribonuclease L (RNase L) following virus-infection of mammalian cells. RNase L degrades both viral and cellular RNAs and restricts virus-proliferation. We have studied organization of RNase L gene in genomic DNA from the mouse liver by Southern blot analysis. Several BamHI, BglII, EcoRI, HincII, HindIII, NcoI, PstI, SacI, and XbaI restriction fragments hybridized to P-32-labeled mouse RNase L cDNA and the 5'-proximal exon probes. Mouse RNase L gene exists as a single copy (> 16 kb DNA) gene. A 5 kb HindIII and a 2.5 kb EcoRI DNA were detected as 5'-upstream DNA of the gene which may contain mouse RNase L promoter. Our results will help studying mouse RNase L gene promoter in further details.

引用

页码：97 / 104

页数：8

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