A new role for GABA: inhibition of tumor cell migration

被引：65
|
作者：
Ortega, A [1 ]
机构：
[1] IPN, Dept Genet & Biol Mol, Cinvestav, Mexico City 07000, DF, Mexico
来源：
TRENDS IN PHARMACOLOGICAL SCIENCES | 2003年 / 24卷 / 04期
关键词：
D O I：
10.1016/S0165-6147(03)00052-X
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
GABA, the main inhibitory neurotransmitter in the vertebrate brain, participates outside the CNS in diverse functions such as platelet aggregation and the acrosomal reaction in spermatozoa. A recent study now demonstrates that GABA inhibits the migration of colon carcinoma cells, paving the way to the development of specific pharmacological agents that delay or inhibit invasion and metastasis of various cancer types.
引用
收藏
页码：151 / 154
页数：4
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