[1] Univ Porto, Unit Pharmacol & Therapeut, Dept Biomed, Fac Med, Porto, Portugal
[2] Sao Joao Hosp Ctr, Dept Gastroenterol, Porto, Portugal
[3] Sao Joao Hosp Univ Ctr, Clin Pharmacol Unit, Porto, Portugal
[4] Vila Nova Gaia Espinho Hosp Ctr, Dept Gastroenterol, Vila Nova De Gaia, Portugal