Engineering quadrupole magnetic flow sorting for the isolation of pancreatic islets

被引：8
|
作者：
Kennedy, David J.
Todd, Paul
Logan, Sam
Becker, Matthew
Papas, Klearchos K.
Moore, Lee R.
机构：
[1] IKOtech LLC, Cincinnati, OH 45219 USA
[2] Univ Minnesota, Diabet Inst Immunol & Transplantat, Minneapolis, MN USA
[3] Cleveland Clin Fdn, Dept Biomed Engn, Cleveland, OH 44195 USA
[4] SHOT Inc, Greenville, IN USA
来源：
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2007年 / 311卷 / 01期
基金：
美国国家卫生研究院;
关键词：
magnetic separation; pancreatic islets; type; 1; diabetes; engineering; cell separation; quadrupole separator;
D O I：
10.1016/j.jmmm.2006.10.1160
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
Quadrupole magnetic flow sorting (QMS) is being adapted from the separation of suspensions of single cells (<15 mu m) to the isolation of pancreatic islets (150-350 mu m) for transplant. To achieve this goal, the critical QMS components have been modeled and engineered to optimize the separation process. A flow channel has been designed, manufactured, and tested. The quadrupole magnet assembly has been designed and verified by finite element analysis. Pumps have been selected and verified by test. Test data generated from the pumps and flow channel demonstrate that the fabricated channel and peristaltic pumps fulfill the requirements of successful QMS separation. (C) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码：388 / 395
页数：8
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