Simultaneous characterization of a mixture of fluorochemicals using three-dimensional 19F-1H heteronuclear TOCSY filtered/edited NMR experiments

被引：13

作者：

Hu, Haitao ^{[1
]}

Kulanthaivel, Palaniappan ^{[1
]}

Krishnamurthy, Krish ^{[1
]}

机构：

[1] Eli Lilly & Co, Discovery Chem Res & Technol & Drug Disposit, Indianapolis, IN 46285 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2007年 / 72卷 / 16期

关键词：

D O I：

10.1021/jo070658w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Heteronuclear F-19-H-1 cross-polarization can be used effectively as a tool for both spectral filtering and editing in the NMR analysis of the increasing number of fluorine-containing compounds encountered in drug discovery. Combined with LC-MS, three-dimensional F-19-H-1 heteronuclear TOCSY filtered experiments based on this approach have enabled the simultaneous identification of a mixture of closely related dexamethasone derivatives without the need for isolation.

引用

页码：6259 / 6262

页数：4

共 28 条

[21] Microstructural characterization of fluoropolymers via two-dimensional H-1/F-19/C-13 triple-resonance NMR techniques
Li, L
Ray, DG
Rinaldi, PL
Wang, HT
Harwood, HJ
MACROMOLECULES, 1996, 29 (13) : 4706 - 4711
[22] 1H and 19F ultra-fast MAS double-quantum single-quantum NMR correlation experiments using three-spin terms of the dipolar homonuclear Hamiltonian
Deschamps, Michael
Fayon, Franck
Cadars, Sylvian
Rollet, Anne-Laure
Massiot, Dominique
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 2011, 13 (17) : 8024 - 8030
[23] Characterization of poly(1-chloro-1-fluoroethylene) fluoropolymer using H-1/C-13/F-19 triple resonance 3D-NMR
Li, L
Rinaldi, PL
MACROMOLECULES, 1997, 30 (03) : 520 - 525
[24] Translation of nucleoside ribohydrolase enzyme assays for purified enzymes to direct measurement of enzyme activity in Trichomonas vaginalis cells using 19F and 13C-edited 1H NMR spectroscopy
Stockman, Brian
Ventura, Carlos
Deykina, Valerie
Lontscharitsch, Nickolas Khayan
Saljanin, Edina
Gil, Ari
Canestrari, Madison
Mahmood, Maham
JOURNAL OF BIOLOGICAL CHEMISTRY, 2023, 299 (03) : S89 - S89
[25] Sequential backbone assignment in 13C-labeled RNA via through-bond coherence transfer using three-dimensional triple resonance spectroscopy (1H, 13C, 31P) and two-dimensional hetero TOCSY
Heus, H.A.
Wijmenga, S.S.
van de Ven, F.J.M.
Hilbers, C.W.
1600, Publ by ACS, Washington, DC, USA (116):
[26] Three-dimensional whole-brain simultaneous T1, T2, and T1ρ quantification using MR Multitasking: Method and initial clinical experience in tissue characterization of multiple sclerosis
Ma, Sen
Wang, Nan
Fan, Zhaoyang
Kaisey, Marwa
Sicotte, Nancy L.
Christodoulou, Anthony G.
Li, Debiao
MAGNETIC RESONANCE IN MEDICINE, 2021, 85 (04) : 1938 - 1952
[27] Characterization of poly(1-fluoro-1-chloroethylene) and poly(1-fluoro-1-chloroethylene-co-isobutylene) monomer and stereosequence distribution using H-1/F-19/C-13 triple resonance 3D-NMR.
Rinaldi, PL
Li, L
Wang, HT
Harwood, HJ
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 213 : 286 - POLY
[28] Whole body MRI at 7 tesla using a 1H/19F elliptic body coil with whole-body, fat-signal insensitive, three dimensional magnetic field shim algorithm
Liebes, Leonard
Lee, Ray
Liu, Songtao
Buckley, Michael T.
Hochster, Howard
Gonen, Oded
MOLECULAR CANCER THERAPEUTICS, 2007, 6 (12) : 3479S - 3479S

← 1 2 3 →