IL-25 in allergic inflammation

被引：105
|
作者：
Xu, Miao
Dong, Chen [1 ,2 ]
机构：
[1] Tsinghua Univ, Inst Immunol, Beijing, Peoples R China
[2] Tsinghua Univ, Sch Med, Beijing, Peoples R China
来源：
IMMUNOLOGICAL REVIEWS | 2017年 / 278卷 / 01期
关键词：
allergic diseases; cell source; cell target; cytokines; IL-25; IL-25-mediated diseases; INNATE LYMPHOID-CELLS; AIRWAY INFLAMMATION; IN-VIVO; INTERLEUKIN-17; RECEPTOR; PULMONARY INFLAMMATION; IMMUNE-RESPONSES; ADAPTER PROTEIN; TYPE-2; IMMUNITY; CYTOKINE IL-25; FAMILY-MEMBERS;
D O I：
10.1111/imr.12558
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
IL-25, also known as IL-17E, is a member of the IL-17 cytokine family mostly produced by epithelial cells and innate immune cells. After binding to the IL-17RB/IL-17RA complex, IL-25 induces downstream signaling responses in epithelial cells and type 2 lymphocytes, which initiates, propagates, and sustains type 2 immunity. The function of IL-25 in allergic diseases such as asthma has been well established, and now also is extended to diseases such as inflammatory bowel disease and cancer. This review summarizes the literature on IL-25 and discusses the unsolved questions. Our knowledge on IL-25 will pave the pathway for targeting this cytokine in inflammatory diseases.
引用
收藏
页码：185 / 191
页数：7
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