HDAC6 at Crossroads of Infection and Innate Immunity

被引：36
|
作者：
Moreno-Gonzalo, Olga [1 ,2 ]
Mayor, Federico, Jr. [3 ,4 ]
Sanchez-Madrid, Francisco [1 ,2 ,4 ]
机构：
[1] CNIC, Vasc Pathophysiol Area, Cell Cell Commun Lab, Melchor Fernandez Almagro 3, Madrid 28029, Spain
[2] Univ Autonoma Madrid, Inst Invest Sanit La Princesa IIS IP, Hosp Univ Princesa, Serv Inmunol, Diego Leon 62, Madrid 28006, Spain
[3] Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa, CSIC, Dept Biol Mol, E-28049 Madrid, Spain
[4] ISCIII CIBERCV, CIBER Enfermedades Cardiovasc, Madrid 28029, Spain
来源：
TRENDS IN IMMUNOLOGY | 2018年 / 39卷 / 08期
关键词：
D O I：
10.1016/j.it.2018.05.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Histone deacetylase 6 (HDAC6) acts by enzyme-dependent and-independent mechanisms to regulate diverse cellular processes including autophagy, the ubiquitin proteasome system, and cell migration. HDAC6 also has emerging roles in innate immunity, including pathogen sensing and destruction, thus placing this enzyme at the crossroads of infection and innate immunity.
引用
收藏
页码：591 / 595
页数：5
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