Fibroblast growth factor-2 and -9 regulate proliferation and production of matrix metalloproteinases in human gliomas

被引：0
|
作者：
Miyagi, N
Kato, S
Terasaki, M
Shigemori, M
Morimatsu, M
机构：
[1] Kurume Univ, Sch Med, Dept Pathol, Kurume, Fukuoka 830, Japan
[2] Kurume Univ, Sch Med, Dept Neurosurg, Kurume, Fukuoka 830, Japan
来源：
INTERNATIONAL JOURNAL OF ONCOLOGY | 1998年 / 12卷 / 05期
关键词：
basic fibroblast growth factor; glia-activating factor; matrix metalloproteinase; tissue inhibitor of metalloproteinase; glioma;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Fibroblast growth factor (FGF) signaling has been recognized in human gliomas. We tested the effect of FGF-2 and FGF-9 on the proliferation and the expression of matrix metalloproteinases (MMPs) and their inhibitor (TIMP-1) in vitro. Both FGFs showed mitogenic activity on U251MG and NMC-G1 cells. MMP-1 expression and collagenolytic activity of NMC-G1 but not of U251MG, and TIMP-1 expression of both cells were stimulated by FGFs. MMP-2 expression, gelatinolytic activity, and chemo-invasion on the matrigel were not altered. FGFs may regulate proliferation and microenvironmental factors independently in each glioma type.
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页码：1085 / 1090
页数：6
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