Synergistic Activities of Three Triazoles with Caspofungin against Candida glabrata Isolates Determined by Time-Kill, Etest, and Disk Diffusion Methods

被引：28
|
作者：
Kiraz, Nuri [1 ]
Dag, Ilknur [2 ]
Yamac, Mustafa [3 ]
Kiremitci, Abdurrahman [1 ]
Kasifoglu, Nilgun [1 ]
Oz, Yasemin [1 ]
机构：
[1] Univ Eskisehir Osmangazi, Dept Microbiol, Fac Med, Eskisehir, Turkey
[2] Univ Eskisehir Osmangazi, Hlth Serv Vocat High Sch, Eskisehir, Turkey
[3] Univ Eskisehir Osmangazi, Dept Biol, Fac Art & Sci, Eskisehir, Turkey
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2010年 / 54卷 / 05期
关键词：
IN-VITRO INTERACTION; BROTH MICRODILUTION METHOD; AMPHOTERICIN-B; ANTIFUNGAL AGENTS; SUSCEPTIBILITY; VORICONAZOLE; COMBINATION; PARAPSILOSIS; FLUCONAZOLE; ASPERGILLUS;
D O I：
10.1128/AAC.01527-09
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Combinations of voriconazole, fluconazole, and itraconazole with caspofungin were evaluated against 50 Candida glabrata isolates by the time-kill, disk diffusion, and Etest methods. The majority of antifungal combinations were indifferent. By the time-kill method, synergistic activity was detected with eight (16%) of the caspofungin-voriconazole and seven (14%) of the caspofungin-fluconazole combinations, but synergy was not seen with the caspofungin-itraconazole combination. Further comparisons of the Etest and disk diffusion synergy techniques with the time-kill method are warranted.
引用
收藏
页码：2244 / 2247
页数：4
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