On 3-D graphical representation of DNA primary sequences and their numerical characterization

被引：286
|
作者：
Randic, M
Vracko, M
Nandy, A
Basak, SC
机构：
[1] Natl Inst Chem, Ljubljana 1001, Slovenia
[2] Iowa State Univ, Ames Lab, US DOE, Ames, IA 50011 USA
[3] Univ Minnesota, Nat Resources Res Inst, Duluth, MN 55811 USA
[4] Indian Inst Chem Biol, Comp Div, Calcutta 700032, W Bengal, India
来源：
JOURNAL OF CHEMICAL INFORMATION AND COMPUTER SCIENCES | 2000年 / 40卷 / 05期
关键词：
D O I：
10.1021/ci000034q
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In this article we (1) outline the construction of a 3-D "graphical" representation of DNA primary sequences, illustrated on a portion of the human beta globin gene; (2) describe a particular scheme that transforms the above 3-D spatial representation of DNA into a numerical matrix representation; (3) illustrate construction of matrix invariants for DNA sequences; and (4) suggest a data reduction based on statistical analysis of matrix invariants generated for DNA. Each of the four contributions represents a novel development that I we hope will facilitate comparative studies of DNA and open new directions for representation and characterization of DNA primary sequences.
引用
收藏
页码：1235 / 1244
页数：10
相关论文
共 50 条
12345