Metabolism, Gliomas, and IDH1

被引：15
|
作者：
Smeitink, Jan [1 ]
机构：
[1] Radboud Univ Nijmegen, Dept Pediat, Med Ctr, NL-6525 ED Nijmegen, Netherlands
来源：
NEW ENGLAND JOURNAL OF MEDICINE | 2010年 / 362卷 / 12期
关键词：
D O I：
10.1056/NEJMcibr0912922
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A mutation in IDH1, which encodes an isocitrate dehydrogenase, is associated with susceptibility to glioma. This mutation results in an acquired enzyme activity that points to a potential biomarker of the mutant tumor.
引用
收藏
页码：1144 / 1145
页数：2
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