Synthesis of novel spiro[benzo[4,5]thiazolo[3,2-a]chromeno[2,3-d] pyrimidine-14,3′-indoline]-1,2′,13(2H)-triones via three component reaction

被引：22
|
作者：
Jannati, Saeideh [1 ]
Esmaeili, Abbas Ali [1 ]
机构：
[1] Ferdowsi Univ Mashhad, Fac Sci, Dept Chem, Mashhad 9177948974, Iran
来源：
TETRAHEDRON | 2018年 / 74卷 / 24期
关键词：
Multicomponent reactions; Cyclohexane-1,3-dione; Tungstophosphoric acid; Spirooxindole; POT 3-COMPONENT SYNTHESIS; N-ALKYL ISATINS; MULTICOMPONENT REACTIONS; THIAZOLOPYRIMIDINE DERIVATIVES; CONVENIENT SYNTHESIS; CONCISE SYNTHESIS; HETEROPOLY ACIDS; EFFICIENT; CHEMISTRY; ANALOGS;
D O I：
10.1016/j.tet.2018.04.092
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new and efficient method for the synthesis of hitherto unreported spiro[benzo[4,5]thiazolo[3,2-a] chromeno[2,3-d]pyrimidine-14,3'-indoline]-1,2',13(2H)-triones was developed via the Domino Knoevenagel condensation-Michael addition-intermolecular cyclization sequences of isatin derivatives, cyclohexane-1,3-diones, and 2-hydroxy-4H-benzo14,51thiazolo[3,2-a]pyrimidin-4-ones, employing 12-tungstophosphoric acid (H3PW12O40) as an effective and inexpensive catalyst. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2967 / 2972
页数：6
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