Research progress of the relationship between pyroptosis and disease

被引：4
|
作者：
Ma, Yuze [1 ,2 ,3 ]
Jiang, Jiaxuan [1 ,2 ,3 ]
Gao, Yuan [1 ,2 ,3 ]
Shi, Tianshu [4 ,5 ]
Zhu, Xiaobo [4 ,5 ]
Zhang, Kaijia [4 ,5 ]
Lu, Ke [1 ,2 ,3 ,4 ,5 ]
Xue, Bin [1 ,2 ,3 ,6 ,7 ]
机构：
[1] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, 22 Hankou Rd, Nanjing 210093, Jiangsu, Peoples R China
[2] Nanjing Univ, Jiangsu Key Lab Mol Med, 22 Hankou Rd, Nanjing 210093, Jiangsu, Peoples R China
[3] Nanjing Univ, Sch Med, 22 Hankou Rd, Nanjing 210093, Jiangsu, Peoples R China
[4] Nanjing Univ, Sch Med, Drum Tower Hosp, Dept Sports Med, 321 Zhongshan Rd, Nanjing 210008, Jiangsu, Peoples R China
[5] Nanjing Univ, Sch Med, Drum Tower Hosp, Dept Adult Reconstruct Surg, 321 Zhongshan Rd, Nanjing 210008, Jiangsu, Peoples R China
[6] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China
[7] Nanjing Univ, Med Sch, Liver Dis Collaborat Res Platform, Nanjing 210093, Jiangsu, Peoples R China
来源：
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2018年 / 10卷 / 07期
基金：
美国国家科学基金会;
关键词：
Pyroptosis; disease; inflammation; cell death; INFLAMMASOME ACTIVATION; GASDERMIN-D; CASPASES; NLRP3; PORE; INHIBITION; MECHANISMS; CHANNEL; PROTEIN; NLRC4;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Pyroptosis, characterized by proinflammation, has been defined as a new type of programmed cell death in recent years. Inflammasomes are activated by the corresponding pathogen-associated molecular patterns (PAMPS) or damage-associated molecular patterns (DAMPS), followed up by the cleavage of pro-interleukin-1 beta (pro-IL-1 beta), pro-interleukin-18 (pro-IL-18) and gasdermin D. The N-terminal fragment of gasdermin D gives rise to the destruction of cell membrane, leading to cell rupture as well as the efflux of proinflammatory cytokines. Recent studies have shown that pyroptosis is associated with a variety of diseases due to its proinflammation effect and the dysfunction of related cells. The relationship between pyroptosis and associated diseases is described in this review.
引用
收藏
页码：2213 / 2219
页数：7
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