Ketamine-An Update on Its Clinical Uses and Abuses

被引：28

作者：

Xu, Jian ^{[1
]}

Lei, Hong ^{[2
]}

机构：

[1] Second Mil Med Univ, Chang Hai Hosp, Dept Lab Med, Shanghai, Peoples R China

[2] Beijing Mil Area Command, Inst Drug & Instrument Control, Beijing 100071, Peoples R China

来源：

CNS NEUROSCIENCE & THERAPEUTICS | 2014年 / 20卷 / 12期

关键词：

Abuse; Antidepressant; Asthmaticus; Ketamine; METHYL-D-ASPARTATE; INTRAVENOUS KETAMINE; CONTINUOUS-INFUSION; STATUS-ASTHMATICUS; ORAL KETAMINE; DOUBLE-BLIND; ANTIDEPRESSANT; GLUTAMATE; RECEPTOR; DEPRESSION;

D O I：

10.1111/cns.12363

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This review highlights the recent clinical research that supports the therapeutic utility of ketamine as a multifaceted drug. After long-term use as a dissociative anesthetic, it has re-emerged as a useful agent for ameliorating pain, asthmaticus, and depression. In addition, it is also a substance of abuse. Chronic ketamine abuse over prolonged periods (weeks, months, and years) can produce toxicity to the gastrointestinal and urinary tract. In this review, we described the recent progress on its clinical uses and abuses.

引用

页码：1015 / 1020

页数：6

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