Treatment of Bowen's disease with photodynamic therapy. Observational study in 171 patients with 5-aminolaevulinic acid (BF-200 ALA) and methyl aminolaevulinate (MAL)

被引：10
|
作者：
Alique-Garcia, Sergio [1 ,2 ]
Alique, Daniel [3 ]
Company-Quiroga, Jaime [1 ]
Sanchez, Alberto [2 ,4 ]
Hernandez Nunez, Almudena [1 ]
Borbujo, J. [1 ]
机构：
[1] Hosp Univ Fuenlabrada, Dept Dermatol, C Camino Molino 2, Madrid 28942, Spain
[2] Univ Rey Juan Carlos, Madrid, Spain
[3] Univ Politecn Madrid, Sch Agr Food & Biosyst Engn, Madrid, Spain
[4] Res Ctr Computat Simulat, Madrid, Spain
来源：
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2019年 / 28卷
关键词：
Bowen's disease; Photodynamic therapy; 5-aminolaevulinic acid; Methyl aminolaevulinate; SQUAMOUS-CELL CARCINOMA; SKIN;
D O I：
10.1016/j.pdpdt.2019.08.011
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
An observational study was carried out in the photodynamic therapy (PDT) section of Fuenlabrada's hospital (Madrid, Spain). Our goal was to investigate the efficacy and safety of PDT in Bowen's disease (BD). Between June 2011-June 2017 171 patients (191 lesions) with diagnosis of BD were enrolled in the study (95 women and 76 men; average age of 74.31 years). Lesions were treated with one 5-aminolaevulinic acid (BF-200 ALA)-PDT or methyl-5-aminolaevulinate (MAL)-PDT cycle of two sessions in one week. A second treatment cycle was performed in cases of clinical persistence at 12 weeks. Our results showed that 47/55 lesions were resolved (84.75%) after one or two ALA-PDT cycle and 75/136 lesions (55.15%) after one or two MAL-PDT cycles, in the 12-month follow-up. In conclusion PDT is a safe and non-invasive treatment option in BD. In addition, our results suggest a better response with ALA-PDT over MAL-PDT. Limits: observational study with a limited number of patients.
引用
收藏
页码：192 / 194
页数：3
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