Radiolytic attack of DNA is modulated by DNA conformation. Monte Carlo simulation

被引：0
|
作者：
Begusova, M
Tartier, L
Savoye, C
Sy, D
Spotheim-Maurizot, M
Charlier, M
Michalik, V
机构：
[1] CNRS, Ctr Biophys Mol, F-45071 Orleans 2, France
[2] Inst Phys Nucl, Dept Dosimetrie Rayonnements, Prague 18086 8, Czech Republic
[3] Univ Orleans, F-45067 Orleans 2, France
来源：
JOURNAL DE CHIMIE PHYSIQUE ET DE PHYSICO-CHIMIE BIOLOGIQUE | 1998年 / 95卷 / 04期
关键词：
DNA structure; DNA radiation damage; simulation Monte Carlo; OH radical;
D O I：
10.1051/jcp:1998177
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To study the influence of DNA structure on the probability of single strand breaks induction by ionising radiations, the attack by OH radicals is simulated by the Monte Carlo method. We have calculated the relative probabilities of OH radical reaction with all the reactive sites of: a) a DNA fragment in B form, containing the sequences AATT and AAATT, and b) an intramolecular DNA quadruplex [G(4)(T(4)G(4))(3)] and the corresponding duplex in B form. The results of our simulations are compared to the experimental values, and the effect of DNA structural variations on single strand breaks yield is discussed.
引用
收藏
页码：674 / 681
页数：8
相关论文
共 50 条
  • [21] Monte Carlo simulations of a polymer chain conformation. The effectiveness of local moves algorithms and estimation of entropy
    Agnieszka Mańka
    Waldemar Nowicki
    Grażyna Nowicka
    Journal of Molecular Modeling, 2013, 19 : 3659 - 3670
  • [22] Monte Carlo simulation of the assembly of bis-biotinylated DNA and streptavidin
    Richter, J
    Adler, M
    Niemeyer, CM
    CHEMPHYSCHEM, 2003, 4 (01) : 79 - 83
  • [23] Monte Carlo simulation on stretching of single DNA molecules in confined environments
    Zhang, HM
    Xie, YJ
    He, XJ
    Shi, QW
    Zhu, PP
    Yang, HY
    CHINESE JOURNAL OF CHEMICAL PHYSICS, 2005, 18 (06) : 1005 - 1009
  • [24] Microscopic Monte Carlo Simulation for DNA Damage Calculations with Oxygen Distribution
    Lai, Y.
    Jia, X.
    Chi, Y.
    MEDICAL PHYSICS, 2020, 47 (06) : E471 - E471
  • [25] Monte Carlo Simulation of Transcriptional Control in 6kbp DNA
    Tokuda, Naoko
    Sasai, Masaki
    Chikenji, George
    BIOPHYSICAL JOURNAL, 2009, 96 (03) : 56A - 56A
  • [26] Facilitated Protein-DNA Binding: Theory and Monte Carlo Simulation
    Park, Kihyun
    Kim, Taejun
    Kim, Hyojoon
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2012, 33 (03): : 971 - 974
  • [27] SIMULATION OF THE HELICAL CONFORMATION OF DNA
    YAMAGUCHI, S
    CRYSTAL RESEARCH AND TECHNOLOGY, 1983, 18 (09) : K107 - K108
  • [28] Monte Carlo simulation of radiolytic attack to 5′-d[T4G4]4 sequence in a unimolecular quadruplex
    Begusova, M
    Tartier, L
    Syt, D
    Spotheim-Maurizot, M
    Michalik, V
    Charlier, M
    INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1999, 75 (07) : 913 - 917
  • [29] Modulated pulse bathymetric lidar Monte Carlo simulation
    Luo, Tao
    Wang, Yabo
    Wang, Rong
    Du, Peng
    Min, Xia
    AOPC 2015: OPTICAL AND OPTOELECTRONIC SENSING AND IMAGING TECHNOLOGY, 2015, 9674
  • [30] Effect of probe density on DNA hybridization in microarrays: A Monte Carlo simulation study
    van den Berg, Matthijs P.
    Stubbs, John M.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2013, 245
12345