Cellulose nanocrystals are effective in inhibiting host cell bacterial adhesion

被引:15
|
作者
D'Orazio, G. [1 ]
Munizza, L. [1 ]
Zampolli, J. [1 ]
Forcella, M. [1 ]
Zoia, L. [2 ]
Fusi, P. [1 ]
Di Gennaro, P. [1 ]
La Ferla, B. [1 ]
机构
[1] Univ Milano Bicocca, Dept Biotechnol & Biosci, Piazza Sci 2, I-20126 Milan, Italy
[2] Univ Milano Bicocca, Dept Earth & Environm Sci, Piazza Sci 1, I-20126 Milan, Italy
关键词
HEPARAN-SULFATE PROTEOGLYCANS; EPITHELIAL-CELLS; LISTERIA-MONOCYTOGENES; GLYCOSAMINOGLYCANS; ADHERENCE; RECEPTOR; BINDING; MACROPHAGES; ATTACHMENT; INVASION;
D O I
10.1039/c7tb01923h
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
The use of cellulose nanocrystals (CNCs) as a biomaterial able to inhibit host cell bacterial adhesion is described. Pre-incubation of E. coli ATCC 25922 with a suspension of 0.1% CNCs afforded a significant 2 log reduction of bacterial adhesion to the intestinal cell monolayer HT29. This effect could be attributed to the interaction between the CNCs and the bacterial cell surface as confirmed using fluorescence microscopy experiments.
引用
收藏
页码:7018 / 7020
页数:3
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