THE ROLE OF LIPOPROTEIN(A) IN THE DEVELOPMENT OF PERIPHERAL AND CAROTID ATHEROSCLEROSIS

被引：0
|
作者：
Tmoyan, N. A. [1 ]
Afanasieva, O., I [1 ]
Ezhov, M., V [1 ]
机构：
[1] Natl Med Res Ctr Cardiol, Moscow, Russia
来源：
KARDIOLOGIYA | 2018年 / 58卷 / 06期
关键词：
lipoprotein (a); peripheral artery disease; carotid atherosclerosis; atherosclerosis of lower limbs arteries; CORONARY-HEART-DISEASE; INTIMA-MEDIA THICKNESS; ISCHEMIC-STROKE; INTERMITTENT CLAUDICATION; SERUM LIPOPROTEIN(A); CARDIOVASCULAR RISK; FAMILIAL HYPERCHOLESTEROLEMIA; APOLIPOPROTEIN(A) ISOFORMS; ARTERIAL-DISEASE; APHERESIS;
D O I：
10.18087/cardio.2018.6.10135
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Lipoprotein(a) [Lp(a)] consists of an LDL-like particle in which the apolipoprotein B100 is covalently bound to apolipoprotein(a) by a single disulfide bond. Lp(a) is synthesized in the liver and its plasma concentration varies from 0 to 400 mg/ dl. Increased level of Lp(a) is considered to be an independent risk factor of cardiovascular diseases and coronary heart disease. Data about the significance of hyperlipoproteinemia(a) in the development of atherosclerosis of peripheral (lower limbs) and carotid arteries remain controversial. This review is devoted to Lp(a), its relationship with atherosclerosis of different vascular beds, as well as modern possibilities of hyperlipoproteinemia(a) correction.
引用
收藏
页码：70 / 78
页数：9
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