[1] Brest Univ, EA GETBO 3878, F-29200 Brest, France
[2] Hop Cavale Blanche, Dept Chest Dis & Internal Med, F-29609 Brest, France
[3] Hop Cavale Blanche, INSERM CIC 1412, F-29609 Brest, France
[4] Hop Morvan, Oncol & Hematol Inst, F-29609 Brest, France
[5] Brest Univ, IBSAM, Genet Genom Fonct & Biotechnol UMR1078, Lab Hematol,Equipe ECLA, F-29200 Brest, France
[6] Ottawa Hosp, Ottawa Hosp Res Inst, Clin Epidemiol Program, Div Clin Hematol, Box 201B,501 Smyth Rd, Ottawa, ON K1H 8L6, Canada