Network pharmacology-based identification of the key mechanism of Qinghuo Rougan Formula acting on uveitis
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作者:
Jing, Changying
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Shandong Univ Tradit Chinese Med, Med Sch Ophthalmol & Optometry, Jinan 250002, Shandong, Peoples R ChinaShandong Univ Tradit Chinese Med, Med Sch Ophthalmol & Optometry, Jinan 250002, Shandong, Peoples R China
Jing, Changying
[1
]
Sun, Zhuolun
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Shandong Univ, Shandong Prov Hosp, Jinan, Shandong, Peoples R ChinaShandong Univ Tradit Chinese Med, Med Sch Ophthalmol & Optometry, Jinan 250002, Shandong, Peoples R China
Sun, Zhuolun
[3
]
Xie, Xiaofeng
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机构:
Shandong Univ Tradit Chinese Med, Inst Eye, Key Lab Integrated Tradit Chinese & Western Med P, Shandong Prov Key Lab Integrated Tradit Chinese &, Jinan 250002, Shandong, Peoples R ChinaShandong Univ Tradit Chinese Med, Med Sch Ophthalmol & Optometry, Jinan 250002, Shandong, Peoples R China
Xie, Xiaofeng
[2
]
Zhang, Xiuyan
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Shandong Univ Tradit Chinese Med, Med Sch Ophthalmol & Optometry, Jinan 250002, Shandong, Peoples R ChinaShandong Univ Tradit Chinese Med, Med Sch Ophthalmol & Optometry, Jinan 250002, Shandong, Peoples R China
Zhang, Xiuyan
[1
]
Wu, Shanshan
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Shandong Univ Tradit Chinese Med, Med Sch Ophthalmol & Optometry, Jinan 250002, Shandong, Peoples R ChinaShandong Univ Tradit Chinese Med, Med Sch Ophthalmol & Optometry, Jinan 250002, Shandong, Peoples R China
Wu, Shanshan
[1
]
Guo, Keying
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Shandong Univ, Shandong Prov Hosp, Jinan, Shandong, Peoples R ChinaShandong Univ Tradit Chinese Med, Med Sch Ophthalmol & Optometry, Jinan 250002, Shandong, Peoples R China
Guo, Keying
[3
]
Bi, Hongsheng
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Shandong Univ Tradit Chinese Med, Inst Eye, Key Lab Integrated Tradit Chinese & Western Med P, Shandong Prov Key Lab Integrated Tradit Chinese &, Jinan 250002, Shandong, Peoples R ChinaShandong Univ Tradit Chinese Med, Med Sch Ophthalmol & Optometry, Jinan 250002, Shandong, Peoples R China
Bi, Hongsheng
[2
]
机构:
[1] Shandong Univ Tradit Chinese Med, Med Sch Ophthalmol & Optometry, Jinan 250002, Shandong, Peoples R China
[2] Shandong Univ Tradit Chinese Med, Inst Eye, Key Lab Integrated Tradit Chinese & Western Med P, Shandong Prov Key Lab Integrated Tradit Chinese &, Jinan 250002, Shandong, Peoples R China
[3] Shandong Univ, Shandong Prov Hosp, Jinan, Shandong, Peoples R China
Background: Qinghuo Rougan Formula (QHRGF) is a traditional Chinese medicine (TCM) that has been widely apllied to treat uveitis for several decades. However, the inhibitory mechanism of QHRGF in uveitis has remained to be an enigma. Methods: The Chinese herbal medicine pharmacology data and analysis platform wereused to search and screen for the effective components of the QHRGF compound injection and to analyse possible therapeutic targets based on network topology. In addition, various known disease target databases were enraolled, the therapeutic target proteins in uveitis were screened, and a protein-protein interaction (PPI) network was constructed. Enrichment analysis was performed on key nodes. Finally, the inhibitory effect of QHRGF on uveitis was verified by experiments. Results: We identified 259 major candidate targets of QHRGF and successfully constructed a 'QHRGF-compound-target-uveitis' network. Above-mentioned targets revealed by Gene enrichment analysis have played an significant role in the cell cycle, autoimmune disease, apoptosis and related signal pathways. We demonstrated that QHRGF attenuates local inflammation in experimental autoimmune uveoretinitis (EAU) rats by regulating natural killer T (NKT) cells and inhibiting MAPK signal pathways. Conclusion: QHRGF may regulate the local immune response and inflammatory factors mainly through the MAPK signal pathway. For autoimmune uveitis, QHRGF may be a promising, long-lasting treatment strategy.
机构:
Emergency Department, Xiyuan Hospital of China Academy of Chinese Medical SciencesEmergency Department, Xiyuan Hospital of China Academy of Chinese Medical Sciences
SHENG Song
YANG Zhi-xu
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Emergency Department, Xiyuan Hospital of China Academy of Chinese Medical SciencesEmergency Department, Xiyuan Hospital of China Academy of Chinese Medical Sciences
YANG Zhi-xu
XU Feng-qin
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Institute of Geriatrics, Xiyuan Hospital of China Academy of Chinese Medical SciencesEmergency Department, Xiyuan Hospital of China Academy of Chinese Medical Sciences
XU Feng-qin
HUANG Ye
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Emergency Department, Xiyuan Hospital of China Academy of Chinese Medical SciencesEmergency Department, Xiyuan Hospital of China Academy of Chinese Medical Sciences
机构:
Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical CollegeInstitute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College
KANG De
PANG Xiao-cong
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Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical CollegeInstitute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College
PANG Xiao-cong
ZHAO Ying
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Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical CollegeInstitute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College
ZHAO Ying
XU Lyu-jie
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Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical CollegeInstitute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College
XU Lyu-jie
LIAN Wen-wen
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Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical CollegeInstitute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College
LIAN Wen-wen
LIU Ai-lin
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Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical CollegeInstitute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College
LIU Ai-lin
DU Guan-hua
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Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical CollegeInstitute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College
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Hebei Univ TCM, Affiliated Hosp, Hebei Prov Hosp Chinese Med, Shijiazhuang 050011, Hebei, Peoples R ChinaHebei Univ TCM, Affiliated Hosp, Hebei Prov Hosp Chinese Med, Shijiazhuang 050011, Hebei, Peoples R China
Li, De-Hui
Su, Yi-Fan
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Hebei Univ TCM, Affiliated Hosp, Hebei Prov Hosp Chinese Med, Shijiazhuang 050011, Hebei, Peoples R China
Hebei Coll Tradit Chinese Med, Grad Sch, Shijiazhuang 050091, Hebei, Peoples R ChinaHebei Univ TCM, Affiliated Hosp, Hebei Prov Hosp Chinese Med, Shijiazhuang 050011, Hebei, Peoples R China
Su, Yi-Fan
Sun, Chun-Xia
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Hebei Univ TCM, Affiliated Hosp, Hebei Prov Hosp Chinese Med, Shijiazhuang 050011, Hebei, Peoples R ChinaHebei Univ TCM, Affiliated Hosp, Hebei Prov Hosp Chinese Med, Shijiazhuang 050011, Hebei, Peoples R China
Sun, Chun-Xia
Fan, Huan-Fang
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Hebei Univ TCM, Affiliated Hosp, Hebei Prov Hosp Chinese Med, Shijiazhuang 050011, Hebei, Peoples R ChinaHebei Univ TCM, Affiliated Hosp, Hebei Prov Hosp Chinese Med, Shijiazhuang 050011, Hebei, Peoples R China
Fan, Huan-Fang
Gao, Wei-Juan
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Hebei Key Lab Chinese Med Res Cardiocerebrovasc D, Shijiazhuang 050011, Hebei, Peoples R ChinaHebei Univ TCM, Affiliated Hosp, Hebei Prov Hosp Chinese Med, Shijiazhuang 050011, Hebei, Peoples R China
机构:
Hunan Univ Tradit Chinese Med, Grad Sch, Changsha 410208, Peoples R China
Hunan Univ Tradit Chinese Med, Affiliated Hosp 1, Changsha 410021, Peoples R ChinaHunan Univ Tradit Chinese Med, Grad Sch, Changsha 410208, Peoples R China
Huang, Yalan
Zhang, Yanling
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Hunan Univ Tradit Chinese Med, Coll Tradit Chinese Med, Changsha 410208, Peoples R China
Ningxia Med Univ, Gen Hosp, Ningxia 750003, Peoples R ChinaHunan Univ Tradit Chinese Med, Grad Sch, Changsha 410208, Peoples R China
Zhang, Yanling
Wu, Yongjun
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Hunan Univ Tradit Chinese Med, Coll Pharm, Changsha 410208, Peoples R ChinaHunan Univ Tradit Chinese Med, Grad Sch, Changsha 410208, Peoples R China
Wu, Yongjun
Xiang, Qin
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Hunan Univ Tradit Chinese Med, Sci & Technol Dept, Changsha 410208, Peoples R ChinaHunan Univ Tradit Chinese Med, Grad Sch, Changsha 410208, Peoples R China
Xiang, Qin
Yu, Rong
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Hunan Univ Tradit Chinese Med, Grad Sch, Changsha 410208, Peoples R ChinaHunan Univ Tradit Chinese Med, Grad Sch, Changsha 410208, Peoples R China
Yu, Rong
DRUG DESIGN DEVELOPMENT AND THERAPY,
2023,
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260
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Hubei Univ Chinese Med, Wuhan 430061, Peoples R China
Hubei Univ Chinese Med, Affiliated Hosp, Wuhan 430061, Peoples R China
Hubei Prov Hosp Tradit Chinese Med, Wuhan 430061, Peoples R China
Hubei Prov Acad Tradit Chinese Med, Wuhan 430073, Peoples R ChinaHubei Univ Chinese Med, Wuhan 430061, Peoples R China
Wen, Feng
Yu, Jun
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Hubei Aerosp Hosp, Xiaogan 432000, Peoples R ChinaHubei Univ Chinese Med, Wuhan 430061, Peoples R China
Yu, Jun
Cheng, Yan
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Hubei Univ Chinese Med, Affiliated Hosp, Wuhan 430061, Peoples R China
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Hubei Prov Acad Tradit Chinese Med, Wuhan 430073, Peoples R ChinaHubei Univ Chinese Med, Wuhan 430061, Peoples R China
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Xi An Jiao Tong Univ, Dept Neurosurg, Affiliated Hosp 1, Xian 710000, Peoples R ChinaXi An Jiao Tong Univ, Dept Neurosurg, Affiliated Hosp 1, Xian 710000, Peoples R China
Wang, Chunpeng
Liu, Xiaohui
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Anyang Canc Hosp, Dept Med Oncol, An Yang 455000, Peoples R ChinaXi An Jiao Tong Univ, Dept Neurosurg, Affiliated Hosp 1, Xian 710000, Peoples R China
Liu, Xiaohui
Guo, Shiwen
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Xi An Jiao Tong Univ, Dept Neurosurg, Affiliated Hosp 1, Xian 710000, Peoples R ChinaXi An Jiao Tong Univ, Dept Neurosurg, Affiliated Hosp 1, Xian 710000, Peoples R China