Central Administration of Ampelopsin A Isolated from Vitis vinifera Ameliorates Cognitive and Memory Function in a Scopolamine-Induced Dementia Model

被引:13
|
作者
Hong, Yuni [1 ,2 ]
Choi, Yun-Hyeok [3 ]
Han, Young-Eun [1 ]
Oh, Soo-Jin [1 ,4 ]
Lee, Ansoo [1 ,2 ]
Lee, Bonggi [5 ]
Magnan, Rebecca [6 ]
Ryu, Shi Yong [7 ]
Choi, Chun Whan [3 ]
Kim, Min Soo [1 ,2 ]
机构
[1] Korea Inst Sci & Technol KIST, Brain Sci Inst, Seoul 02792, South Korea
[2] Univ Sci & Technol, KIST Sch, Div Biomed Sci & Technol, Seoul 02792, South Korea
[3] Gyeonggido Business & Sci Accelerator, Gyeonggi Bioctr, Nat Prod Res Team, Suwon 16229, South Korea
[4] KIST, Convergence Res Ctr Dementia, Seoul 02792, South Korea
[5] Pukyong Natl Univ, Dept Food Sci & Nutr, Busan 48513, South Korea
[6] Pomona Coll, Dept Neurosci, Claremont, CA 91711 USA
[7] Korea Res Inst Chem Technol, Daejeon 34122, South Korea
基金
新加坡国家研究基金会;
关键词
ampelopsin A; Vitis vinifera; memory behavioral tests; long-term potentiation; CREB; BDNF signals; LONG-TERM POTENTIATION; NEUROTROPHIC FACTOR; ALZHEIMERS-DISEASE; STILBENE DERIVATIVES; PROTEIN-SYNTHESIS; BDNF; CREB; RESVERATROL; INHIBITORS; EXTRACT;
D O I
10.3390/antiox10060835
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Neurodegenerative diseases are characterized by the progressive degeneration of the function of the central nervous system or peripheral nervous system and the decline of cognition and memory abilities. The dysfunctions of the cognitive and memory battery are closely related to inhibitions of neurotrophic factor (BDNF) and brain-derived cAMP response element-binding protein (CREB) to associate with the cholinergic system and long-term potentiation. Vitis vinifera, the common grapevine, is viewed as the important dietary source of stilbenoids, particularly the widely-studied monomeric resveratrol to be used as a natural compound with wide-ranging therapeutic benefits on neurodegenerative diseases. Here we found that ampelopsin A is a major compound in V. vinifera and it has neuroprotective effects on experimental animals. Bath application of ampelopsin A (10 ng/mu L) restores the long-term potentiation (LTP) impairment induced by scopolamine (100 mu M) in hippocampal CA3-CA1 synapses. Based on these results, we administered the ampelopsin A (10 ng/mu L, three times a week) into the third ventricle of the brain in C57BL/6 mice for a month. Chronic administration of ampelopsin A into the brain ameliorated cognitive memory-behaviors in mice given scopolamine (0.8 mg/kg, i.p.). Studies of mice's hippocampi showed that the response of ampelopsin A was responsible for the restoration of the cholinergic deficits and molecular signal cascades via BDNF/CREB pathways. In conclusion, the central administration of ampelopsin A contributes to increasing neurocognitive and neuroprotective effects on intrinsic neuronal excitability and behaviors, partly through elevated BDNF/CREB-related signaling.
引用
收藏
页数:18
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