Hematopoietic stem cell transplantation in multiple myeloma

被引：11
|
作者：
Pant, Shubham
Copelan, Edward A.
机构：
[1] Cleveland Clin Fdn, Dept Hematol Oncol & Blood Disorders, Taussig Canc Ctr, Cleveland, OH 44195 USA
[2] Ohio State Univ, Div Hematol & Oncol, Columbus, OH 43210 USA
来源：
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2007年 / 13卷 / 08期
关键词：
multiple myeloma; hematopoietic stem cell transplantation;
D O I：
10.1016/j.bbmt.2007.05.002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
High-dose therapy and autologous hematopoietic stem cell transplantation are standard early treatment of patients with multiple myeloma. Tandem transplantation appears to provide additional benefit, particularly in patients with limited response to initial transplantation. Myeloablative allogeneic transplantation provides the only potential for cure, but has been largely abandoned because of high mortality rates. Newer and better induction regimens, rigorous analysis of results with autologous and allogeneic transplantation, and the development of risk-adapted stratification provide the impetus for this critical evaluation of the role of hematopoietic stem cell transplantation in multiple myeloma. (c) 2007 American Society for Blood and Marrow Transplantation
引用
收藏
页码：877 / 885
页数：9
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