共 25 条
- [1] Discovery and initial SAR of imidazoquinoxalines as inhibitors of the Src-family kinase p56LckBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2002, 12 (10) : 1361 - 1364Chen, PNorris, DIwanowicz, EJSpergel, SHLin, JGu, HHShen, ZQWityak, JLin, TAPang, SHDe Fex, HFPitt, SShen, DRDoweyko, AMBassolino, DARoberge, JYPoss, MAChen, BCSchieven, GLBarrish, JC
- [2] Discovery and initial SAR of 2-amino-5-carboxamidothiazoles as inhibitors of the Src-family kinase p56LckBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (22) : 4007 - 4010Wityak, JDas, JMoquin, RVShen, ZQLin, JChen, PDoweyko, AMPitt, SPang, SHShen, DRFang, Qde Fex, HFSchieven, GLKanner, SBBarrish, JC
- [3] Discovery of 2-amino-heteroaryl-benzothiazole-6-anilides as potent p56lck inhibitorsBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2003, 13 (15) : 2587 - 2590Das, JMoquin, RVLin, JLiu, CJDoweyko, AMDeFex, HFFang, QPang, SHPitt, SShen, DRSchieven, GLBarrish, JCWityak, J
- [4] INTERACTION OF THE IL-2 RECEPTOR WITH THE SRC-FAMILY KINASE-P56LCK - IDENTIFICATION OF NOVEL INTERMOLECULAR ASSOCIATIONSCIENCE, 1991, 252 (5012) : 1523 - 1528HATAKEYAMA, MKONO, TKOBAYASHI, NKAWAHARA, ALEVIN, SDPERLMUTTER, RMTANIGUCHI, T
- [5] Imidazoquinoxaline Src-family kinase p56Lck inhibitors:: SAR, QSAR, and the discovery of (S)-N-(2-chloro-6-methylphenyl)-2-(3-methyl-1-piperazinyl)imidazo[1,5-a]pyrido[3,2-e]pyrazin-6-amine (BMS-279700) as a potent and orally active inhibitor with excellent in vivo antiinflammatory activityJOURNAL OF MEDICINAL CHEMISTRY, 2004, 47 (18) : 4517 - 4529Chen, PDoweyko, AMNorris, DGu, HHSpergel, SHDas, JMoquin, RVLin, JWityak, JIwanowicz, EJMcIntyre, KWShuster, DJBehnia, KChong, Sde Fex, HPang, SHPitt, SShen, DRThrall, SStanley, PKocy, ORWitmer, MRKanner, SBSchieven, GLBarrish, JC
- [6] Ligands for the tyrosine kinase p56lck SH2 domain:: Discovery of potent dipeptide derivatives with monocharged, nonhydrolyzable phosphate replacementsJOURNAL OF MEDICINAL CHEMISTRY, 1999, 42 (10) : 1757 - 1766Beaulieu, PLCameron, DRFerland, JMGauthier, JGhiro, EGillard, JGorys, VPoirier, MRancourt, JWernic, DLlinas-Brunet, MBetageri, RCardozo, MHickey, ERIngraham, RJakes, SKabcenell, AKirrane, TLukas, SPatel, UProudfoot, JSharma, RTong, LMoss, N
- [7] Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) InhibitorsJOURNAL OF MEDICINAL CHEMISTRY, 2023, 66 (11) : 7534 - 7552Hartz, Richard A.Ahuja, Vijay T.Luo, GuanglinChen, LingSivaprakasam, PrasannaXiao, HongKrause, Carol M.Clarke, Wendy J.Xu, SongmeiTokarski, John S.Kish, KevinLewis, HalSzapiel, NicolasRavirala, RamuMutalik, SayaliNakmode, DeepaShah, DevangBurton, Catherine R.Macor, John E.Dubowchik, Gene M.
- [8] Ligands for the tyrosine kinase p56lck SH2 domain:: Discovery of potent dipeptides with monocharged, non-hydrolyzable phosphate replacements.ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1998, 216 : U281 - U281Beaulieu, PLCameron, DRFerland, JMGauthier, JChiro, EGillard, JGorys, VPoirier, MRancourt, JWernic, DLlinas-Brunet, MBetageri, RKirrane, TSharma, RHickey, GPatel, UProudfoot, JMoss, NCardozo, MJakes, SLukas, SKabcenell, ATong, LIngraham, R
- [9] 5-cyanopyrimidine derivatives as a novel class of potent, selective, and orally active inhibitors of p38α MAP kinaseJOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (20) : 6261 - 6270Liu, CJWrobleski, STLin, JAhmed, GMetzger, AWityak, JGillooly, KMShuster, DJMcIntyre, KWPitt, SShen, DRZhang, RFZhang, HJDoweyko, AMDiller, DHenderson, IBarrish, JCDodd, JHSchieven, GLLeftheris, K
- [10] 4-Thiophenoxy-N-(3,4,5-trialkoxyphenyl)pyrimidine-2-amines as potent and selective inhibitors of the T-cell tyrosine kinase p56lckCURRENT MEDICINAL CHEMISTRY, 2004, 11 (06) : 747 - 753Moffat, DFCAllen, RARapecki, SEDavis, PDO'Connell, JHutchings, MCKing, MABoyce, BAPerry, MJ