Beyond the brain: Optogenetic control in the spinal cord and peripheral nervous system

被引：117

作者：

Montgomery, Kate L. ^{[1
]}

Iyer, Shrivats M. ^{[1
]}

Christensen, Amelia J. ^{[2
]}

Deisseroth, Karl ^{[1
,3
,4
]}

Delp, Scott L. ^{[1
,5
]}

机构：

[1] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Elect Engn, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA

[4] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA

[5] Stanford Univ, Dept Mech Engn, Stanford, CA 94305 USA

来源：

SCIENCE TRANSLATIONAL MEDICINE | 2016年 / 8卷 / 337期

关键词：

OPTICAL CONTROL; GENE-TRANSFER; ELECTRICAL-STIMULATION; NOCICEPTIVE NEURONS; CHEMOGENETIC TOOLS; IMMUNE-RESPONSES; TRANSGENIC MICE; MUSCLE FUNCTION; AAV VECTORS; VAGUS-NERVE;

D O I：

10.1126/scitranslmed.aad7577

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Optogenetics offers promise for dissecting the complex neural circuits of the spinal cord and peripheral nervous system and has therapeutic potential for addressing unmet clinical needs. Much progress has been made to enable optogenetic control in normal and disease states, both in proof-of-concept and mechanistic studies in rodent models. In this Review, we discuss challenges in using optogenetics to study the mammalian spinal cord and peripheral nervous system, synthesize common features that unite the work done thus far, and describe a route forward for the successful application of optogenetics to translational research beyond the brain.

引用

页数：12

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