Stress induced cognitive deficit is differentially modulated in BALB/c and C57Bl/6 mice Correlation with Th1/Th2 balance after stress exposure

被引：48
|
作者：
Palumbo, M. L. [1 ]
Canzobre, M. C. [2 ]
Pascuan, C. G. [1 ]
Rios, H. [2 ]
Wald, M. [1 ]
Genaro, A. M. [1 ]
机构：
[1] Univ Buenos Aires, Fac Med, CONICET, CEFYBO,Catedra Farmacol 1A, RA-1121 Buenos Aires, DF, Argentina
[2] Univ Buenos Aires, Fac Med, Inst Biol Celular & Neurociencias Prof De Roberti, RA-1121 Buenos Aires, DF, Argentina
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2010年 / 218卷 / 1-2期
关键词：
Chronic mild stress; Hippocampus; Learning and memory; Th1/Th2; balance; Reactive oxygen species; BALB/c and C57BL/6 inbred strains of mice; CHRONIC MILD STRESS; MEMORY IMPAIRMENT; IMMUNE-RESPONSE; SPATIAL MEMORY; HIPPOCAMPUS; EXPRESSION; HORMONES; MODEL; INTERLEUKIN-1; PERFORMANCE;
D O I：
10.1016/j.jneuroim.2009.11.005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
This work shows a comparative study on the effects of chronic mild stress upon learning and memory and immunity, in BALB/c and C57BL/6 mice. Stressed BALB/c, but not C57Bl/6 mice, showed a poor learning performance, morphological alterations in the hippocampus with an increase in oxidative stress. A Correlation between poor memory performance and the increase of the Th2/Th1 balance was found. Our results suggest that vulnerability to cognitive deficit associated with stress exposition could be related to a differential regulation of Th1/Th2 cytokine balance, suggesting a better learning performance for individuals that produce Th1 type cytokine after stress exposition. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：12 / 20
页数：9
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