Decreased serum levels of adiponectin in subjects with autism

被引：31

作者：

Fujita-Shimizu, Azusa ^{[1
]}

Suzuki, Katsuaki ^{[2
]}

Nakamura, Kazuhiko ^{[1
]}

Miyachi, Taishi ^{[2
]}

Matsuzaki, Hideo ^{[3
]}

Kajizuka, Masanobu ^{[1
]}

Shinmura, Chie ^{[1
]}

Iwata, Yasuhide ^{[1
]}

Suda, Shiro ^{[2
]}

Tsuchiya, Kenji J. ^{[2
]}

Matsumoto, Kaori ^{[2
]}

Sugihara, Genichi ^{[2
]}

Iwata, Keiko ^{[2
]}

Yamamoto, Shigeyuki ^{[2
]}

Tsujii, Masatsugu ^{[2
,4
]}

Sugiyama, Toshiro ^{[5
]}

Takei, Nori ^{[2
]}

Mori, Norio ^{[1
,2
]}

机构：

[1] Hamamatsu Univ Sch Med, Dept Psychiat & Neurol, Hamamatsu, Shizuoka 4313192, Japan

[2] Hamamatsu Univ Sch Med, Osaka Hamamatsu Joint Res Ctr Child Mental Dev, Hamamatsu, Shizuoka 4313192, Japan

[3] Osaka Univ, Osaka Hamamatsu Joint Res Ctr Child Mental Dev, Grad Sch Med, Osaka, Japan

[4] Chukyo Univ, Fac Sociol, Aichi, Japan

[5] Aichi Childrens Hlth & Med Ctr, Aichi, Japan

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2010年 / 34卷 / 03期

关键词：

Adiponectin; Autism; Inflammatory events; Serum; BLOOD-BRAIN-BARRIER; CHILDREN; DISORDERS;

D O I：

10.1016/j.pnpbp.2009.12.020

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The neurobiological basis for autism remains poorly understood. We hypothesized that adipokines, such as adiponectin, may play a role in the pathophysiology of autism. In this study, we examined whether serum levels of adiponectin are altered in subjects with autism. We measured serum levels of adiponectin in male subjects with autism (n = 31) and age-matched healthy male subjects (n = 31). The serum levels of adiponectin in the subjects with autism were significantly lower than that of normal control subjects. The serum adiponectin levels in the subjects with autism were negatively correlated with their domain A scores in the Autism Diagnostic Interview Revised, which reflects their impairments in social interaction. This study suggests that decreased levels of serum adiponectin might be implicated in the pathophysiology of autism. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：455 / 458

页数：4

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